CAS 289042-10-0: Rosuvastatin Intermediates ZD9

Description: Rosuvastatin Intermediates ZD9, with the CAS number 289042-10-0, is a chemical compound that serves as an intermediate in the synthesis of rosuvastatin, a widely used statin medication for lowering cholesterol levels. This compound typically exhibits characteristics common to organic intermediates, including a specific molecular structure that facilitates its role in chemical reactions. It is likely to be a solid at room temperature, with moderate solubility in organic solvents, which is typical for many pharmaceutical intermediates. The compound may possess functional groups that are reactive, allowing it to participate in further synthetic transformations. Safety data sheets would indicate handling precautions, as intermediates can often be hazardous. Additionally, its purity and stability are crucial for the efficiency of the final product synthesis. Overall, Rosuvastatin Intermediates ZD9 plays a vital role in the pharmaceutical industry, contributing to the production of effective cholesterol-lowering therapies.

Formula: C₂₈H₂₉FN₃O₃PS

InChI: InChI=1S/C28H29FN3O3PS/c1-20(2)26-25(19-36(33,23-11-7-5-8-12-23)24-13-9-6-10-14-24)27(21-15-17-22(29)18-16-21)31-28(30-26)32(3)37(4,34)35/h5-18,20H,19H2,1-4H3

InChI key: InChIKey=CVRDGWDBQZPJJI-UHFFFAOYSA-N

SMILES: O=P(C=1C=CC=CC1)(C=2C=CC=CC2)CC=3C(=NC(=NC3C(C)C)N(C)S(=O)(=O)C)C=4C=CC(F)=CC4

Synonyms:

• 4-(4-Fluorophenyl)-5-(diphenylphosphinyl)methyl-6-isopropyl-2-[(N-methyl-n-methylsulfonyl)amino]pyrimidine
• Methanesulfonamide, N-[5-[(diphenylphosphinyl)methyl]-4-(4-fluorophenyl)-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl-
• N-[5-(Diphenyl-phosphinoylmethyl)-4-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-2-yl]-N-methyl-methanesulfonamide
• N-[5-(Diphenylphosphinoylmethyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
• N-[5-[(Diphenylphosphinyl)methyl]-4-(4-fluorophenyl)-6-(1-methylethyl)-2-pyrimidinyl]-N-methylmethanesulfonamide
• N-{5-[(diphenylphosphoryl)methyl]-4-(4-fluorophenyl)-6-(1-methylethyl)pyrimidin-2-yl}-N-methylmethanesulfonamide
• Z-8.1
• -4-(4-fluorophenyl)
• Diphenyl[4-(4-fluorophenyl)-6-isopropyl-2-[(2-n-Methyl-n-Methylsulfonyl)aMino]pyriMidine-5-yl-Methyl]phosphine oxide
• Rosuvastatin Intermediates ZD9
• N-(5-((Diphenylphosphoryl)methyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethan
• isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide(Z8.3)
• N-[5-(Diphenylphosphinoylmethyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfon
• Diphenyl[4-(4-Fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonyl)amino-pyrimidin-5-yl-methyl]phosph
• N-(5-((Diphenylphosphoryl)methyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesu
• N-(5-((Diphenylphosphoryl)
• Triphenyl[4-(4-fluorophenyl)-6-isopropyl-2-[(2-n-methyl-n-methylsulfonyl)amino]pyrimidine-5-yl-methyl]phosphine bromine
• N-(5-((Diphenylphosphoryl)Methyl)-4-(4-fluorophenyl)-6-isopropylpyriMidin-2-yl)-N-MethylMethanesulfonaMide
• -6-isopropylpyrimidin-2-yl)
• N-[5-(diphenylphosphorylmethyl)-4-(4-fluorophenyl)-6-propan-2-ylpyrimidin-2-yl]-N-methylmethanesulfonamide
• 4-(4-fluorophenyl)-6-isopropyl-2-[(n-methyl-n-methylsulfonyl)amino] pyriminl-5-yl- phosphine oxide
• Diphenyl [4-(4-fluorophenyl)- 6-isopropyl-2-[(n-Methyl- n-ethylsulfonyl)aMino] pyriMidine-5-yl- ethyl]phosphine
• Diphenyl[4-(4-Fluorophenyl)-6-isopropyl-2-(N-MethylMethylsulfonyl)aMino-pyriMidin-5-yl-Methyl]phosphine Oxide
• Z-8: DIPHENYL [4-(4-FLUOROPHENYL)-6-ISOPROPYL-2-[(N-METHYL-N-METHYLSULFONYL) AMINO] PYRIMIDINE-5-YL-METHYL] PHOSPHINE OXIDE
• N-[5-(Diphenylphosphinoylmethyl)-4-(4-fluorophenyl)-6-
• Rosuvastatin InterMediate Z-8.1
• rosuvastatin intermediates Z-8.1
• Rosuvastatin Diphenylphosphine Oxide

Methanesulfonamide, N-[5-[(diphenylphosphinyl)methyl]-4-(4-fluorophenyl)-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl-

CAS: 289042-10-0

• Formula: C₂₈H₂₉FN₃O₃PS
• Purity: 97%
• Color and Shape: Solid
• Molecular weight: 537.5853

N-[5-[(Diphenylphosphinyl)methyl]-4-(4-fluorophenyl)-6-(1-methylethyl)-2-pyrimidinyl]-N-methylmethanesulfonamide

CAS: 289042-10-0

• Color and Shape: Neat

Rosuvastatin Impurity 133

CAS: 289042-10-0

• Formula: C₂₈H₂₉FN₃O₃PS
• Molecular weight: 537.59

Rosuvastatin Impurity 37

CAS: 289042-10-0

• Formula: C₂₈H₂₉FN₃O₃PS
• Molecular weight: 537.59

Diphenyl[4-(4-Fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonyl)amino-pyrimidin-5-yl-methyl]phosphine Oxide

CAS: 289042-10-0

Applications An intermediate in the production of Rosuvastatin (R700500) derivatives. References Liu, Y. et al.: …

• Formula: C₂₈H₂₉FN₃O₃PS
• Color and Shape: Neat
• Molecular weight: 537.59

Diphenyl[4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonyl)amino-pyrimidin-5-yl-methyl]phosphine oxide

CAS: 289042-10-0

Diphenyl[4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonyl)amino-pyrimidin-5-yl-methyl]phosphine oxide is an inhibitor of the reductase enzyme, which is involved in the synthesis …

• Formula: C₂₈H₂₉FN₃O₃PS
• Purity: Min. 95%
• Molecular weight: 537.59 g/mol