CAS 28920-43-6

9-Fluorenylmethyl chloroformate

Description:

9-Fluorenylmethyl chloroformate, with the CAS number 28920-43-6, is an organic compound commonly used as a reagent in organic synthesis, particularly in the field of peptide and amino acid chemistry. It features a fluorenylmethyl group, which enhances its reactivity and solubility in organic solvents. The compound is characterized by its chloroformate functional group, which is known for its ability to form carbamates upon reaction with amines. This property makes it valuable for protecting amino groups during multi-step synthesis processes. 9-Fluorenylmethyl chloroformate is typically a colorless to pale yellow liquid, and it is sensitive to moisture and air, necessitating careful handling and storage under inert conditions. Its reactivity can be attributed to the electrophilic nature of the carbonyl carbon in the chloroformate group, allowing it to participate in nucleophilic substitution reactions. Overall, this compound is an important tool in synthetic organic chemistry, particularly for the protection and activation of functional groups.

Formula: C₁₅H₁₁ClO₂

InChI: InChI=1S/C15H11ClO2/c16-15(17)18-9-14-12-7-3-1-5-10(12)11-6-2-4-8-13(11)14/h1-8,14H,9H2

InChI key: InChIKey=IRXSLJNXXZKURP-UHFFFAOYSA-N

SMILES: C(OC(Cl)=O)C1C=2C(C=3C1=CC=CC3)=CC=CC2

Synonyms:

• (9H-Fluoren-9-ylmethoxy)carbonyl chloride
• 9-Fluorenylmethoxycarbonyl
• 9-Fluorenylmethoxycarbonyl chloride
• 9-Fluorenylmethyl chlorocarbonate
• 9-Fluorenylmethyloxycarbonylchloride
• 9H-Fluoren-9-ylmethylchlorformiat
• 9H-fluoren-9-ylmethyl carbonochloridate
• 9H-fluoren-9-ylmethyl chloroformate
• AminoTag
• Carbonic acid, monoanhydride with carbonochloridic acid, 9H-fluoren-9-ylmethyl ester
• Carbonochloridic acid, 9H-fluoren-9-ylmethyl ester
• Chloroformate, (9-Fluorenylmethyl)
• Chloroformiate de 9H-fluoren-9-ylmethyle
• Chloroformic acid 9-fluorenylmethyl ester
• FMOC-chloride
• Fluorene-9-methanol, chloroformate
• Fluorenylmethyl chloroformate
• Fmoc-Cl
• FmocCl
• Formic acid, chloro-, fluoren-9-ylmethyl ester
• chloroformiate de 9H-fluorene-9-ylmethyle
• cloroformiato de 9H-fluoren-9-ilmetilo

9-Fluorenylmethyl Chloroformate [N-Protecting Agent for Peptides Research]

CAS: 28920-43-6

Formula: C₁₅H₁₁ClO₂

Purity: >97.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystaline

Molecular weight: 258.70

Ref: 3B-F0197

9-Fluorenylmethyl chloroformate, 98+%

CAS: 28920-43-6

Base sensitive amino protecting group for solid-phase peptide synthesis9-Fluorenylmethyl chloroformate is used in capillary electrophoresis. It acts as a reagent in the precolumn derivatization of amines for HPLC and fluorescent detection. Further, it is used for derivatizing amino acids for HPLC an

Formula: C₁₅H₁₁ClO₂

Purity: 98+%

Color and Shape: White or cream or pale yellow, Powder

Molecular weight: 258.70

Ref: 02-A11683

Fmoc-Cl

CAS: 28920-43-6

Reagent for the introduction of the Fmoc-amino-protecting group, which is stable towards acids and catalytic hydrogenation but is readily cleaved under mildly basic non-hydrolytic conditions. The use of this reagent in the protection of hydroxy groups and amino groups in nucleotides has been reported as well. Fmoc-chloride is often used for pre-column derivatization of amines and amino acids in analytical HPLC.

Formula: C₁₅H₁₁ClO₂

Purity: 98.9%

Color and Shape: Whitish

Molecular weight: 258.7

Ref: 01-4004776

9H-Fluoren-9-ylmethyl chloroformate

CAS: 28920-43-6

Formula: C₁₅H₁₁ClO₂

Purity: 96%

Color and Shape: Solid

Molecular weight: 258.6996

Ref: IN-DA002X2Y

Fmoc chloride

CAS: 28920-43-6

Formula: C₁₅H₁₁ClO₂

Purity: ≥ 97.0%

Color and Shape: White to off-white or pale yellow-orange crystalline powder

Molecular weight: 258.70

Ref: 7W-GE3236

(9H-Fluoren-9-yl)methyl chloroformate

CAS: 28920-43-6

(9H-Fluoren-9-yl)methyl chloroformate

Formula: C₁₅H₁₁ClO₂

Purity: ≥95%

Color and Shape: white to light yellow to orange crystal or chunks or powder

Molecular weight: 258.69964g/mol

Ref: 54-OR13210

Fmoc-Chloride

CAS: 28920-43-6

Formula: C₁₅H₁₁ClO₂

Purity: 97.0%

Color and Shape: Solid

Molecular weight: 258.7

Ref: 10-F022072

(9-Fluorenylmethyl) Chloroformate

CAS: 28920-43-6

Formula: C₁₅H₁₁ClO₂

Molecular weight: 258.70

Ref: 4Z-C-334007

9-Fluorenylmethyl Chlorocarbonate

CAS: 28920-43-6

Stability Moisture Sensitive
Applications 9-Fluorenylmethyl Chlorocarbonate is an N-Protecting agent for peptides research and was used for the pre-column derivatization of the biogenic amines (BAs) cadaverine (Cad), histamine (Him), octopamine (Ocp), phenylethylamine (Pea), putrescine (Put), spermidine (Spd), spermine (Spm), tyramine (Tym).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Rebane, R., et al.: J. Chromatograph. Anal. Technol. Biomed. Life. Sci., 904, 99 (2012); Brueckner, H., et al.: Amino. Acids., 42, 877 (2012);

Formula: C₁₅H₁₁ClO₂

Color and Shape: Light Yellow

Molecular weight: 258.70

Ref: TR-F472450

Fmoc-Cl

CAS: 28920-43-6

Fmoc-Cl is a fluorescent derivative that can be used as an analytical method for amino acids in human serum. This reagent is synthesized from chloroformate and derivatization of the amino acid with polymyxin B. Fmoc-Cl reacts with amino acids, producing a fluorescent molecule. The reaction solution can be applied to human serum to determine the concentration of various types of amino acids in the sample. The main matrix effect comes from the presence of human serum proteins, which have been shown to interfere with the measurement of some amino acid concentrations. Fmoc-Cl has also been studied as a potential therapeutic agent for autoimmune diseases, such as multiple sclerosis, lupus erythematosus, and rheumatoid arthritis. It has been shown that Fmoc-Cl inhibits complex enzymes and can reduce levels of certain inflammatory markers in animal models.

Formula: C₁₅H₁₁ClO₂

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 258.7 g/mol

Ref: 3D-FF07779

9-Fluorenylmethyl Chloroformate (FMOC Chloride, FMOC-Cl) extrapure, 99%

CAS: 28920-43-6

Formula: C₁₅H₁₁ClO₂

Purity: min. 99%

Color and Shape: White to off-white, Crystalline powder

Molecular weight: 258.70

Ref: SR-54083