PARP10/15-IN-2, identified by its CAS number 2892064-99-0, is a small molecule inhibitor targeting poly(ADP-ribose) polymerases (PARPs), specifically PARP10 and PARP15. These enzymes play crucial roles in cellular processes such as DNA repair, cell proliferation, and apoptosis. The inhibition of PARP10 and PARP15 has garnered interest in cancer research, particularly in the context of enhancing the efficacy of chemotherapy and targeted therapies. The compound is characterized by its ability to selectively bind to the active sites of these PARP enzymes, thereby interfering with their activity. This selectivity is essential for minimizing off-target effects and maximizing therapeutic potential. In addition to its biochemical properties, PARP10/15-IN-2 is typically evaluated for its solubility, stability, and bioavailability, which are critical factors for its application in preclinical and clinical studies. Overall, this compound represents a promising avenue for therapeutic intervention in cancers that exhibit reliance on PARP-mediated pathways.

PARP10/15-IN-2

2892064-99-0: PARP10/15-IN-2, identified by its CAS number 2892064-99-0, is a small molecule inhibitor targeting poly(ADP-ribose) polymerases (PARPs), specifically PARP10 and PARP15. These enzymes play crucial roles in cellular processes such as DNA repair, cell proliferation, and apoptosis. The inhibition of PARP10 and PARP15 has garnered interest in cancer research, particularly in the context of enhancing the efficacy of chemotherapy and targeted therapies. The compound is characterized by its ability to selectively bind to the active sites of these PARP enzymes, thereby interfering with their activity. This selectivity is essential for minimizing off-target effects and maximizing therapeutic potential. In addition to its biochemical properties, PARP10/15-IN-2 is typically evaluated for its solubility, stability, and bioavailability, which are critical factors for its application in preclinical and clinical studies. Overall, this compound represents a promising avenue for therapeutic intervention in cancers that exhibit reliance on PARP-mediated pathways.

<p>PARP10/15-IN-2 (Compound 8h) blocks PARP10/15, has IC50s: 0.15μM/0.37μM, cell-permeable, prevents apoptosis.</p>

CAS 2892064-99-0

PARP10/15-IN-2

PARP10/15-IN-2

Ref: TM-T60567