CAS 289472-78-2

N-((S)-1-(((R)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide

Description:

N-((S)-1-(((R)-1-Hydroxy-3-Methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide, with CAS number 289472-78-2, is a complex organic compound characterized by its unique structural features. It contains a pyrazine ring, which is a six-membered aromatic heterocycle with two nitrogen atoms, contributing to its potential biological activity. The presence of multiple functional groups, including an amide, hydroxyl, and amino groups, suggests that this compound may exhibit significant interactions with biological systems, potentially influencing its solubility and reactivity. The stereochemistry indicated by the (S) and (R) designations suggests that the compound has chiral centers, which can affect its pharmacological properties and interactions with biological targets. Such compounds are often investigated for their potential therapeutic applications, particularly in fields like medicinal chemistry and drug development. Overall, the structural complexity and functional diversity of this compound make it a subject of interest in chemical and pharmaceutical research.

Formula: C₁₉H₂₄N₄O₃

Synonyms:

• Bortezomib (EP) Impurity E
• (S,R)-Bortezomib Hydroxyisopentyl Amide Analog
• Bortezomib Impurity 2 (S,R-Isomer)
• Bortezomib USP Related Compoud I
• Bortezomib USP Impurity I
• Bortezomib Impurity 2 (SR-Isomer, Bortezomib Impurity E)
• 2-PyrazinecarboxaMide, N-[(1S)-2-[[(1R)-1-hydroxy-3-Methylbutyl]aMino]-2-oxo-1-(phenylMethyl)ethyl]-
• BortezoMib IMpurity 2 (SR-IsoMer, EP IMpurity E)
• SR-Isomer, Bortezomib Impurity E
• Bortezomib impurity 5/Bortezomib EP Impurity E
• N-((S)-1-(((R)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide
• Bortezomib (1S,2R) Isomer Impurity
• (N-[(1R)-1-hydroxy-3-Methylbutyl]-Nα-(pyrazin-2-ylcarbonyl)-L-phenylalaninaMide
• Bortezomib USP IMP I
• (R)-Hydroxy Des(boric Acid) BortezoMib
• N-[(1S)-2-[[(1R)-1-hydroxy-3-methylbutyl]amino]-2-oxo-1-(phenylmethyl)ethyl]pyrazin
• N-[(1S)-2-[[(1R)-1-Hydroxy-3-methylbutyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-2-pyrazinecarboxamide

2-Pyrazinecarboxamide, N-[(1S)-2-[[(1R)-1-hydroxy-3-methylbutyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-

CAS: 289472-78-2

Formula: C₁₉H₂₄N₄O₃

Purity: 99%

Color and Shape: Solid

Molecular weight: 356.4189

Ref: IN-DA002X5T

Bortezomib Impurity 2 (S,R-Isomer)

CAS: 289472-78-2

Formula: C₁₉H₂₄N₄O₃

Color and Shape: White To Off-White Solid

Molecular weight: 356.43

Ref: 4Z-B-4615

(R)-Hydroxy Des(boric Acid) Bortezomib

Controlled Product

CAS: 289472-78-2

Impurity Bortezomib USP Impurity I
Applications (R)-Hydroxy Des(boric acid) Bortezomib is an impurity in the synthesis of Bortezomib (B675700), the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Targets the ubiquitin-proteasome pathway.
References Nawrocki, S.T., et al: Cancer Research, 65, 11510 (2005); Drahl C. et al.: Chem. and Eng. News, 87, 41 (2009)

Formula: C₁₉H₂₄N₄O₃

Color and Shape: Neat

Molecular weight: 356.42

Ref: TR-H935900

(S,R)-Bortezomib Hydroxyisopentyl Amide Analog

CAS: 289472-78-2

Formula: C₁₉H₂₄N₄O₃

Molecular weight: 356.42

Ref: ST-EA-CP-B34005