CAS 289472-81-7

N-((S)-1-(((S)-1-Hydroxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide

CAS: 289472-81-7

Formula: C₁₉H₂₄N₄O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 356.4189

Ref: IN-DA002X5R

Bortezomib Impurity 48

CAS: 289472-81-7

Formula: C₁₉H₂₄N₄O₃

Color and Shape: White To Off-White Solid

Molecular weight: 356.43

Ref: 4Z-B-4612

(S)-Hydroxy Des(boric Acid) Bortezomib

Controlled Product

CAS: 289472-81-7

Impurity Bortezomib USP Impurity J
Applications (S)-Hydroxy Des(boric Acid) Bortezomib is an impurity in the synthesis of Bortezomib (B675700), the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Targets the ubiquitin-proteasome pathway.
References Nawrocki, S.T., et al: Cancer Research, 65, 11510 (2005); Drahl, C. et al.: Chem. and Eng. News, 87, 41 (2009)

Formula: C₁₉H₂₄N₄O₃

Color and Shape: Neat

Molecular weight: 356.42

Ref: TR-H935905

(S)-Hydroxy Des(boric Acid) Bortezomib

CAS: 289472-81-7

Formula: C₁₉H₂₄N₄O₃

Molecular weight: 356.42

Ref: ST-EA-CP-B34008