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CAS 289499-45-2

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Canertinib dihydrochloride

Description:
Canertinib dihydrochloride is a small molecule tyrosine kinase inhibitor primarily used in cancer therapy. It specifically targets the epidermal growth factor receptor (EGFR) and is known for its potential efficacy against various solid tumors, particularly those with EGFR mutations. The dihydrochloride form indicates that the compound is a salt, enhancing its solubility and stability in pharmaceutical formulations. Canertinib is characterized by its ability to inhibit cell proliferation and induce apoptosis in cancer cells by blocking the signaling pathways associated with tumor growth and survival. Its chemical structure includes a quinazoline core, which is common among EGFR inhibitors. The compound is typically administered orally and has been studied in clinical trials for its effectiveness in treating conditions such as non-small cell lung cancer and head and neck cancers. As with many targeted therapies, potential side effects may include skin rash, diarrhea, and liver enzyme elevation, necessitating careful monitoring during treatment.
Formula:C24H25ClFN5O3·2ClH
InChI:InChI=1S/C24H25ClFN5O3.2ClH/c1-2-23(32)30-21-13-17-20(14-22(21)34-9-3-6-31-7-10-33-11-8-31)27-15-28-24(17)29-16-4-5-19(26)18(25)12-16;;/h2,4-5,12-15H,1,3,6-11H2,(H,30,32)(H,27,28,29);2*1H
InChI key:InChIKey=JZZFDCXSFTVOJY-UHFFFAOYSA-N
SMILES:N(C=1C2=C(C=C(OCCCN3CCOCC3)C(NC(C=C)=O)=C2)N=CN1)C4=CC(Cl)=C(F)C=C4.Cl
Synonyms:
  • 2-Propenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-quinazolinyl]-, dihydrochloride
  • 2-Propenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-quinazolinyl]-, hydrochloride (1:2)
  • Canertinib 2HCl
  • Ci 1033
  • N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]prop-2-enamide dihydrochloride
  • N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[2-(morpholin-4-yl)ethoxy]quinazolin-6-yl}prop-2-enamide dihydrochloride
  • N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(morpholin-4-yl)propoxy]quinazolin-6-yl}prop-2-enamide dihydrochloride
  • Pd 183805
  • Canertinib dihydrochloride
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