CAS 2898-76-2

Benzamil

Description:

Benzamil, with the CAS number 2898-76-2, is a chemical compound classified as a benzyl derivative of a dihydropyridine. It is primarily recognized for its role as a selective blocker of calcium channels, particularly in cardiac and smooth muscle tissues. This compound exhibits properties that make it useful in pharmacological applications, particularly in the treatment of hypertension and certain cardiac conditions. Benzamil is known to inhibit calcium influx through voltage-gated calcium channels, thereby reducing vascular resistance and lowering blood pressure. In terms of physical characteristics, it is typically a white to off-white crystalline solid, with moderate solubility in organic solvents and limited solubility in water. Its molecular structure includes a benzyl group, contributing to its lipophilicity, which influences its bioavailability and pharmacokinetics. As with many pharmacologically active compounds, safety and toxicity profiles are essential considerations, and appropriate handling and usage guidelines should be followed in laboratory and clinical settings.

Formula: C₁₃H₁₄ClN₇O

InChI: InChI=1/C13H14ClN7O.ClH/c14-9-11(16)20-10(15)8(19-9)12(22)21-13(17)18-6-7-4-2-1-3-5-7;/h1-5H,6H2,(H4,15,16,20)(H3,17,18,21,22);1H

InChI key: InChIKey=KXDROGADUISDGY-UHFFFAOYSA-N

SMILES: C(NC(NCC1=CC=CC=C1)=N)(=O)C=2C(N)=NC(N)=C(Cl)N2

Synonyms:

• 2-Pyrazinecarboxamide, 3,5-diamino-6-chloro-N-[imino[(phenylmethyl)amino]methyl]-
• 3,5-Diamino-6-chloro-N-(imino((phenylmethyl)amino)methyl)pyrazinecarboxamide
• 3,5-Diamino-6-chloro-N-[imino[(phenylmethyl)amino]methyl]-2-pyrazinecarboxamide
• 3,5-diamino-N-(N'-benzylcarbamimidoyl)-6-chloropyrazine-2-carboxamide
• 3,5-diamino-N-(benzylcarbamimidoyl)-6-chloropyrazine-2-carboxamide hydrochloride
• Benzamil
• Benzylamiloride
• N-(N-Benzylamidino)-3,5-diamino-6-chloropyrazine carboxamide
• Pyrazinecarboxamide, 3,5-diamino-6-chloro-N-(imino((phenylmethyl)amino)methyl)-
• Pyrazinecarboxamide, 3,5-diamino-N-(benzylamidino)-6-chloro-
• BENZAMIL HYDROCHLORIDE
• 5-diamino-6-chloropyrazine carboxamide
• 3,5-Diamino-6-chloro-N-[amino(benzylimino)methyl]pyrazine-2-carboxamide
• N-(BENZYLAMIDINO)-3,5-DIAMINO-6-CHLOROPYRAZINECARBOXAMIDE HCL
• AMILORIDE, BENZYL-, HCL
• BENZAMIL HCL
• BENZYLAMILORIDE HCL
• 3,5-DIAMINO-N-[AMINOBENZYLAMINOMETHYLENE]-6-CHLOROPYRAZINE-2-CARBOXAMIDE
• N-(N-Benzylamidino)-3
• C13751
• BENZYLAMILORIDE HYDROCHLORIDE
• 3,5-DIAMINO-[AMINO-(BENZYLAMINO)METHYLENE]-6-CHLORO-PYRAZINECARBOXAMIDE HYDROCHLORIDE
• 3,5-Diamino-6-chloro-N-[amino(benzylamino)methylene]-2-pyrazinecarboxamide

Benzamil

CAS: 2898-76-2

Benzamil

Purity: ≥98%

Molecular weight: 319.75g/mol

Ref: 54-BUP10313

Benzamil

CAS: 2898-76-2

Benzamil blocks ENaC, inhibiting sodium transport (IC50=4 nM) and binds with Kd=5 nM to bovine kidney membranes.

Formula: C₁₃H₁₄ClN₇O

Purity: 99.79%

Color and Shape: Solid

Molecular weight: 319.75

Ref: TM-T5850