CAS 289893-26-1

3-Pyridinecarboximidoyl chloride, N-[(2R)-2-hydroxy-3-(1-piperidinyl)propoxy]-, 1-oxide, (2Z)-2-butenedioate (1:1)

Description:

3-Pyridinecarboximidoyl chloride, N-[(2R)-2-hydroxy-3-(1-piperidinyl)propoxy]-, 1-oxide, (2Z)-2-butenedioate (1:1) is a complex organic compound characterized by its unique structural features, which include a pyridine ring, an imidoyl chloride functional group, and a piperidine moiety. The presence of the hydroxyl group contributes to its potential reactivity and solubility in polar solvents. This compound is likely to exhibit properties typical of both pyridine derivatives and imidoyl chlorides, such as nucleophilicity and the ability to participate in various chemical reactions, including acylation and coupling reactions. The (2Z)-2-butenedioate component suggests that it may also possess some degree of unsaturation, which can influence its reactivity and stability. Additionally, the presence of a chiral center in the structure indicates that it may exhibit stereochemical properties, potentially leading to different biological activities or interactions. Overall, this compound's intricate structure suggests a range of applications in medicinal chemistry and synthetic organic chemistry, although specific applications would depend on further research and characterization.

Formula: C₁₈H₂₄ClN₃O₇

SMILES: C(=NOC[C@@H](CN1CCCCC1)O)(Cl)C2=CN(=O)=CC=C2.C(=C\C(O)=O)\C(O)=O

Synonyms:

• 3-Pyridinecarboximidoyl chloride, N-[(2R)-2-hydroxy-3-(1-piperidinyl)propoxy]-, 1-oxide, (2Z)-2-butenedioate (1:1) (salt)
• BRX 220
• 3-Pyridinecarboximidoyl chloride, N-[(2R)-2-hydroxy-3-(1-piperidinyl)propoxy]-, 1-oxide, (2Z)-2-butenedioate (1:1)
• AriMocloMol Maleic Acid
• ARIMOCLOMOL MALEATE; BRX-220; BRX 220; BRX220; BRX-345; BRX 345; BRX345.
• ARIMOCLOMOL MALEATE (BRX-220)
• BRX 345
• (2R)-Arimoclomol maleate
• BRX220
• (2R)-Arimoclomol Maleic Acid
• BRX345.

Arimoclomol maleate

CAS: 289893-26-1

Arimoclomol maleate (BRX-220) (BRX-220) is a heat shock protein (HSP) co-inducer.

Formula: C₁₈H₂₄ClN₃O₇

Purity: 99.44% - 99.98%

Color and Shape: Solid

Molecular weight: 429.85

Ref: TM-T13554

Arimoclomol maleate

CAS: 289893-26-1

Arimoclomol maleate

Purity: ≥98%

Molecular weight: 429.85g/mol

Ref: 54-BUP14338

(2R)-Arimoclomol maleate

CAS: 289893-26-1

(2R)-Arimoclomol maleate is an investigational pharmaceutical compound, which is an orally bioavailable small molecule with pharmacological activity primarily targeting cellular protein homeostasis mechanisms. This therapeutic agent is derived from molecular chaperones and operates by selectively enhancing the expression of heat shock proteins (HSPs). The mechanism of action involves the modulation of the heat shock response, wherein (2R)-Arimoclomol maleate amplifies the natural cellular defense pathways against protein misfolding and aggregation.

Formula: C₁₈H₂₄ClN₃O₇

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 429.85 g/mol

Ref: 3D-FA159627

(2R)-Arimoclomol Maleic Acid

Controlled Product

CAS: 289893-26-1

Applications Arimoclomol is a orally administered drug used to treat amyotrophic lateral sclerosis and was later discovered to be a potential insulin resistance treatment and diabetic complications.
References Kurthy, M., et al.: New. York. Acad. Sci., 967, 482 (2002); Kalmar, B., et al.: Exp. Neurol., 184, 636 (2003);

Formula: C₁₈H₂₄ClN₃O₇

Color and Shape: Neat

Molecular weight: 429.85

Ref: TR-A771270

(2R)-Arimoclomol-d10 Maleic Acid

Controlled Product

CAS: 289893-26-1

Formula: C₁₄D₁₀H₁₀ClN₃O₃·C₄H₄O₄

Color and Shape: Neat

Molecular weight: 439.914

Ref: TR-A771272