CAS 290296-72-9

N-DesMethyl Netupitant

Description:

N-Desmethyl Netupitant, with the CAS number 290296-72-9, is a chemical compound that serves as a metabolite of Netupitant, a substance used primarily in the prevention of chemotherapy-induced nausea and vomiting. This compound is characterized by its structural modifications that result in the absence of a methyl group, which influences its pharmacological properties. N-Desmethyl Netupitant exhibits high affinity for neurokinin-1 (NK1) receptors, which play a crucial role in the emetic response. Its mechanism of action involves antagonism of these receptors, thereby inhibiting the effects of substance P, a neuropeptide associated with nausea and vomiting. The compound is typically administered in conjunction with other antiemetic agents to enhance therapeutic efficacy. In terms of physical properties, N-Desmethyl Netupitant is expected to be a solid at room temperature, with solubility characteristics that facilitate its use in pharmaceutical formulations. Safety and toxicity profiles are evaluated through clinical studies, ensuring its suitability for patient use in managing nausea and vomiting associated with cancer treatments.

Formula: C₂₉H₃₀F₆N₄O

Synonyms:

• Netupitant Impurity B
• Netupitant N-Desmethyl Impurity
• N-DesMethyl Netupitant
• 2-(3,5-bis(trifluoromethyl)phenyl)-N,2-dimethyl-N-(6-(piperazin-1-yl)-4-(o-tolyl)pyridin-3-yl)propanamide
• Benzeneacetamide, N,α,α-trimethyl-N-[4-(2-methylphenyl)-6-(1-piperazinyl)-3-pyridinyl]-3,5-bis(trifluoromethyl)-
• Netupitant metabolite N-desmethyl Netupitant

2-(3,5-Bis(trifluoromethyl)phenyl)-N,2-dimethyl-N-(6-(piperazin-1-yl)-4-(o-tolyl)pyridin-3-yl)propanamide

CAS: 290296-72-9

2-(3,5-Bis(trifluoromethyl)phenyl)-N,2-dimethyl-N-(6-(piperazin-1-yl)-4-(o-tolyl)pyridin-3-yl)propanamide

Purity: 99%

Molecular weight: 564.57g/mol

Ref: 54-PC1007886

N-Desmethyl Netupitant

CAS: 290296-72-9

Formula: C₂₉H₃₀F₆N₄O

Color and Shape: Yellow Solid

Molecular weight: 564.58

Ref: 4Z-N-075007

N-Desmethyl Netupitant

Controlled Product

CAS: 290296-72-9

Formula: C₂₉H₃₀F₆N₄O

Color and Shape: Neat

Molecular weight: 564.565

Ref: TR-D292235

N-Desmethyl Netupitant-d6

Controlled Product

CAS: 290296-72-9

Formula: C₂₉D₆H₂₄F₆N₄O

Color and Shape: Neat

Molecular weight: 570.602

Ref: TR-D292237

N-Desmethyl Netupitant

CAS: 290296-72-9

Formula: C₂₉H₃₀F₆N₄O

Molecular weight: 564.58

Ref: ST-EA-CP-F117002

N-desmethyl Netupitant

CAS: 290296-72-9

N-desmethyl Netupitant is a metabolite of Netupitant and a potential Substance-P receptor agonist.

Formula: C₂₉H₃₀F₆N₄O

Purity: 98%

Color and Shape: Solid

Molecular weight: 564.57

Ref: TM-T12212