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CAS 290296-72-9

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N-DesMethyl Netupitant

Description:
N-Desmethyl Netupitant, with the CAS number 290296-72-9, is a chemical compound that serves as a metabolite of Netupitant, a substance used primarily in the prevention of chemotherapy-induced nausea and vomiting. This compound is characterized by its structural modifications that result in the absence of a methyl group, which influences its pharmacological properties. N-Desmethyl Netupitant exhibits high affinity for neurokinin-1 (NK1) receptors, which play a crucial role in the emetic response. Its mechanism of action involves antagonism of these receptors, thereby inhibiting the effects of substance P, a neuropeptide associated with nausea and vomiting. The compound is typically administered in conjunction with other antiemetic agents to enhance therapeutic efficacy. In terms of physical properties, N-Desmethyl Netupitant is expected to be a solid at room temperature, with solubility characteristics that facilitate its use in pharmaceutical formulations. Safety and toxicity profiles are evaluated through clinical studies, ensuring its suitability for patient use in managing nausea and vomiting associated with cancer treatments.
Formula:C29H30F6N4O
Synonyms:
  • Netupitant Impurity B
  • Netupitant N-Desmethyl Impurity
  • N-DesMethyl Netupitant
  • 2-(3,5-bis(trifluoromethyl)phenyl)-N,2-dimethyl-N-(6-(piperazin-1-yl)-4-(o-tolyl)pyridin-3-yl)propanamide
  • Benzeneacetamide, N,α,α-trimethyl-N-[4-(2-methylphenyl)-6-(1-piperazinyl)-3-pyridinyl]-3,5-bis(trifluoromethyl)-
  • Netupitant metabolite N-desmethyl Netupitant
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