CAS 290297-26-6

Netupitant

Description:

Netupitant is a selective neurokinin-1 (NK1) receptor antagonist primarily used in the prevention of nausea and vomiting associated with chemotherapy. It is often combined with palonosetron, a 5-HT3 receptor antagonist, to enhance its efficacy. The molecular formula of netupitant indicates that it contains carbon, hydrogen, nitrogen, and oxygen atoms, reflecting its organic nature. This compound is characterized by its high affinity for the NK1 receptor, which plays a crucial role in the emetic response. Netupitant is typically administered orally and is well-absorbed in the gastrointestinal tract. Its pharmacokinetics show a relatively long half-life, allowing for once-daily dosing. The substance is generally well-tolerated, with common side effects including fatigue, constipation, and headache. Due to its mechanism of action, netupitant is particularly effective in managing chemotherapy-induced nausea and vomiting, making it a valuable therapeutic option in oncology settings.

Formula: C₃₀H₃₂F₆N₄O

InChI: InChI=1S/C30H32F6N4O/c1-19-8-6-7-9-23(19)24-17-26(40-12-10-38(4)11-13-40)37-18-25(24)39(5)27(41)28(2,3)20-14-21(29(31,32)33)16-22(15-20)30(34,35)36/h6-9,14-18H,10-13H2,1-5H3

InChI key: InChIKey=WAXQNWCZJDTGBU-UHFFFAOYSA-N

SMILES: N(C(C(C)(C)C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)=O)(C)C=2C(=CC(=NC2)N3CCN(C)CC3)C4=C(C)C=CC=C4

Synonyms:

• 2-[3,5-Bis(trifluoromethyl)phenyl]-N-[6-(4-methylpiperazin-1-yl)-4-o-tolylpyridin-3-yl]-N-methylisobutyramide
• Benzeneacetamide, N,alpha,alpha-trimethyl-N-(4-(2-methylphenyl)-6-(4-methyl-1-piperazinyl)-3-pyridinyl)-3,5-bis(trifluoromethyl)-
• Benzeneacetamide, N,α,α-trimethyl-N-[4-(2-methylphenyl)-6-(4-methyl-1-piperazinyl)-3-pyridinyl]-3,5-bis(trifluoromethyl)-
• N,α,α-Trimethyl-N-[4-(2-methylphenyl)-6-(4-methyl-1-piperazinyl)-3-pyridinyl]-3,5-bis(trifluoromethyl)benzeneacetamide
• Netupitan
• Netupitant
• Ro 67-31898/000

Benzeneacetamide, N,α,α-trimethyl-N-[4-(2-methylphenyl)-6-(4-methyl-1-piperazinyl)-3-pyridinyl]-3,5-bis(trifluoromethyl)-

CAS: 290297-26-6

Formula: C₃₀H₃₂F₆N₄O

Purity: 99%

Color and Shape: Solid

Molecular weight: 578.5917

Ref: IN-DA002V9C

Netupitant

CAS: 290297-26-6

Netupitant

Purity: ≥98%

Molecular weight: 578.59g/mol

Ref: 54-BUP13389

2-(3,5-Bis(Trifluoromethyl)Phenyl)-N,2-Dimethyl-N-(6-(4-Methylpiperazin-1-Yl)-4-(O-Tolyl)Pyridin-3-Yl)Propanamide

CAS: 290297-26-6

2-(3,5-Bis(Trifluoromethyl)Phenyl)-N,2-Dimethyl-N-(6-(4-Methylpiperazin-1-Yl)-4-(O-Tolyl)Pyridin-3-Yl)Propanamide

Purity: 99%

Molecular weight: 578.59g/mol

Ref: 54-PC109174

Netupitant

CAS: 290297-26-6

Formula: C₃₀H₃₂F₆N₄O

Color and Shape: White To Off-White Solid

Molecular weight: 578.60

Ref: 4Z-N-075001

NETUPITANT

CAS: 290297-26-6

Purity: 95%

Molecular weight: 578.60302734375

Ref: 10-F856948

Netupitant

CAS: 290297-26-6

Netupitant (CID 6451149) is a specific neurokinin 1 (NK1) receptor antagonist (Ki: 0.95 nM).

Formula: C₃₀H₃₂F₆N₄O

Purity: 99.43%

Color and Shape: Solid

Molecular weight: 578.59

Ref: TM-T6905

Netupitant

Controlled Product

CAS: 290297-26-6

Applications Netupitant is a potent and selective neurokinin-1 receptor (NK1) receptor antagonist. It is achiral and orally active.
References Hoffmann, T., et al.: Bioorg. Med. Chem. Lett., 16, 1362 (2006); Di Fabio, R., et al.: Bioorg. Med. Chem., 21, 6264 (2013)

Formula: C₃₀H₃₂F₆N₄O

Color and Shape: Neat

Molecular weight: 578.59

Ref: TR-N390950

Netupitant

CAS: 290297-26-6

Netupitant is an antiemetic drug that is used to treat bowel disease. It has been shown in a two-way crossover study to have biological properties in the treatment of disease activity. Netupitant inhibits the neurokinin-1 receptor and matrix effect, which are responsible for the development of cancerous cells. The drug also has inhibitory properties on p-gp substrates and netupitant, which prevents it from being absorbed by the gastrointestinal tract. This allows netupitant to be transported through the blood-brain barrier into malignant brain tumours, where it can act as a cytotoxic agent.

Purity: Min. 95%

Ref: 3D-FN103430