CAS 29110-48-3

Guanfacine hydrochloride

Description:

Guanfacine hydrochloride is a medication primarily used to treat attention deficit hyperactivity disorder (ADHD) and hypertension. It is an alpha-2 adrenergic agonist, which means it works by stimulating alpha-2 receptors in the brain, leading to decreased sympathetic outflow and reduced blood pressure. The substance appears as a white to off-white crystalline powder and is soluble in water, making it suitable for oral administration. Its chemical formula is C9H9ClN2, and it has a molecular weight of approximately 182.63 g/mol. Guanfacine hydrochloride is known for its sedative effects, which can be beneficial in managing ADHD symptoms by promoting calmness and focus. The drug is typically administered in tablet form, with dosing adjusted based on individual patient response and tolerability. Common side effects may include drowsiness, dry mouth, and fatigue. As with any medication, it is essential to use guanfacine hydrochloride under the guidance of a healthcare professional to ensure safety and efficacy.

Formula: C₉H₁₀Cl₃N₃O

InChI: InChI=1/C9H9Cl2N3O.ClH/c10-6-2-1-3-7(11)5(6)4-8(15)14-9(12)13;/h1-3H,4H2,(H4,12,13,14,15);1H

InChI key: InChIKey=DGFYECXYGUIODH-UHFFFAOYSA-N

SMILES: C(C(NC(=N)N)=O)C1=C(Cl)C=CC=C1Cl.Cl

Synonyms:

• 2,6-Dichlorophenylacetylguanidine hydrochloride
• Benzeneacetamide, N-(aminoiminomethyl)-2,6-dichloro-, hydrochloride (1:1)
• Benzeneacetamide, N-(aminoiminomethyl)-2,6-dichloro-, monohydrochloride
• Bs 100-141
• Estulic
• Guanfacine HCl
• Guanfacine hydrochloride [USAN:JAN]
• Intuniv
• Lon 798
• N-(Aminoiminomethyl)-2,6-dichlorobenzeneacetamide hydrochloride
• N-(Aminoiminomethyl)-2,6-dichlorophenylacetamide monohydrochloride
• N-Amidino-2-(2,6-dichlorophenyl)acetamide hydrochloride
• N-Amidino-2-(2,6-dichlorophenyl)acetamide monohydrochloride
• Spd 503
• Tenex
• Tenex (pharmaceutical)
• Unii-Pml56A160O
• [(2,6-Dichlorophenyl)acetyl]guanidine monohydrochloride
• n-(aminoiminomethyl)-2,6-dichlorobenzeneacetamidehydrochloride
• [(2,6-DICHLOROPHENYL)ACETYL]GUANIDINE HYDROCHLORIDE
• N (AMINOIMINOMETHYL)-2,6-DICHLOROBENZENEACETAMIDE HYDROCHLORIDE SALT
• Guarfacine
• Guanfascine
• GUANFACINE HYDROCHLORIDE
• GUANFACIN HYDROCHLORIDE
• n-(aminoiminomethyl)-2,6-dichloro-benzeneacetamidmonohydrochloride
• n-amidino-2-(2,6-dichlorophenyl)acetamidehydrochloride
• bs100-141
• lon798

Guanfacine Hydrochloride

CAS: 29110-47-2, 29110-48-3

Formula: C₉H₉Cl₂N₃O·HCl

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 282.55

Ref: 3B-G0414

Guanfacine Hydrochloride

CAS: 29110-48-3

Aromatic imines and their derivatives, salts thereof

Formula: C₉H₉Cl₂N₃O·HCI

Color and Shape: White Off-White Crystalline Powder

Molecular weight: 282.55 g/mol

Ref: 45-1302101

Benzeneacetamide, N-(aminoiminomethyl)-2,6-dichloro-, hydrochloride (1:1)

CAS: 29110-48-3

Formula: C₉H₁₀Cl₃N₃O

Purity: 99%

Color and Shape: Solid

Molecular weight: 282.5542

Ref: IN-DA002XC9

N-Carbamimidoyl-2-(2,6-Dichlorophenyl)Acetamide Hydrochloride

CAS: 29110-48-3

N-Carbamimidoyl-2-(2,6-Dichlorophenyl)Acetamide Hydrochloride

Purity: 99%

Molecular weight: 282.55g/mol

Ref: 54-OR1014312

Guanfacine hydrochloride

CAS: 29110-48-3

Guanfacine hydrochloride

Purity: ≥98%

Molecular weight: 282.55g/mol

Ref: 54-BUP13678

Guanfacine HCl

CAS: 29110-48-3

Formula: C₉H₉Cl₂N₃O·HCl

Color and Shape: Off-White Solid

Molecular weight: 246.09 36.46

Ref: 4Z-G-184

Guanfacine hydrochloride

CAS: 29110-48-3

Guanfacine hydrochloride (Intuniv) is a centrally acting antihypertensive agent with specificity towards ADRENERGIC ALPHA-2 RECEPTORS.

Formula: C₉H₁₀Cl₃N₃O

Purity: 99.89% - 99.91%

Color and Shape: Solid

Molecular weight: 282.55

Ref: TM-T2150

Guanfacine hydrochloride

CAS: 29110-48-3

Formula: C₉H₉Cl₂N₃O·HCl

Purity: ≥ 98.0%

Color and Shape: White to almost white crystalline powder

Molecular weight: 282.55

Ref: 7W-GP1667

Guanfacine Hydrochloride

CAS: 29110-48-3

Formula: C₉H₉Cl₂N₃O·ClH

Color and Shape: Neat

Molecular weight: 282.55

Ref: TR-G816001

N-Carbamimidoyl-2-(2,6-dichlorophenyl)acetamide hydrochloride

CAS: 29110-48-3

Formula: C₉H₁₀Cl₃N₃O

Purity: 99%

Molecular weight: 282.55

Ref: 10-F234921

Guanfacine HCl

CAS: 29110-48-3

Guanfacine is a centrally acting alpha-2 adrenergic agonist that is used in the treatment of hypertension and attention deficit hyperactivity disorder (ADHD). It is a racemic mixture of two enantiomers, (+) and (-) guanfacine. Guanfacine acts on central alpha-2 receptors to reduce sympathetic outflow from the vasomotor center, which leads to reduced peripheral vascular resistance, decreased blood pressure, and increased heart rate. It also has been shown to increase the release of gamma-aminobutyric acid (GABA), a neurotransmitter that inhibits neuronal activity. Guanfacine is metabolized by CYP3A4 and CYP2D6 enzymes with elimination half-life of 10 hours. The drug has minimal drug interactions due to its low protein binding properties. Guanfacine has been found to be safe for use in humans at doses up to 3 mg/kg/day

Formula: C₉H₉Cl₂N₃O·HCl

Purity: Min. 95%

Molecular weight: 282.55 g/mol

Ref: 3D-FG33962