IKZF1-degrader-1, identified by its CAS number 2915586-02-4, is a small molecule designed to selectively degrade the IKZF1 protein, which is a transcription factor involved in immune regulation and hematopoiesis. This compound is part of a class of drugs known as proteolysis-targeting chimeras (PROTACs), which harness the cellular ubiquitin-proteasome system to promote the degradation of specific proteins. The characteristics of IKZF1-degrader-1 include its ability to bind to IKZF1 and recruit E3 ubiquitin ligases, leading to the ubiquitination and subsequent proteasomal degradation of the target protein. This mechanism allows for a more nuanced approach to modulating protein levels compared to traditional inhibitors, potentially reducing off-target effects. The compound is of interest in therapeutic contexts, particularly in treating certain hematological malignancies where IKZF1 plays a critical role. Its development reflects ongoing research into targeted protein degradation as a strategy for drug discovery and development in oncology and other fields.

IKZF1-degrader-1

2915586-02-4: IKZF1-degrader-1, identified by its CAS number 2915586-02-4, is a small molecule designed to selectively degrade the IKZF1 protein, which is a transcription factor involved in immune regulation and hematopoiesis. This compound is part of a class of drugs known as proteolysis-targeting chimeras (PROTACs), which harness the cellular ubiquitin-proteasome system to promote the degradation of specific proteins. The characteristics of IKZF1-degrader-1 include its ability to bind to IKZF1 and recruit E3 ubiquitin ligases, leading to the ubiquitination and subsequent proteasomal degradation of the target protein. This mechanism allows for a more nuanced approach to modulating protein levels compared to traditional inhibitors, potentially reducing off-target effects. The compound is of interest in therapeutic contexts, particularly in treating certain hematological malignancies where IKZF1 plays a critical role. Its development reflects ongoing research into targeted protein degradation as a strategy for drug discovery and development in oncology and other fields.

<p>IKZF1-degrader-1 (Compound 9-B) serves as a potent degrader of the IKZF1 protein, exhibiting a DC50 of 0.134 nM. It is applicable in the degradation of tumors [1].</p>

CAS 2915586-02-4

IKZF1-degrader-1

IKZF1-degrader-1

Ref: TM-T86707