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CAS 29177-84-2

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Ethyl loflazepate

Description:
Ethyl loflazepate is a chemical compound classified as a benzodiazepine derivative, primarily known for its anxiolytic and sedative properties. It is characterized by its ability to enhance the effects of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABA-A receptor, leading to increased inhibitory neurotransmission in the central nervous system. This mechanism contributes to its therapeutic effects in treating anxiety and sleep disorders. Ethyl loflazepate is typically administered in its ester form, which is converted into its active metabolite, loflazepate, in the body. The compound is generally recognized for its relatively long half-life, which allows for sustained effects. In terms of physical properties, ethyl loflazepate is a white to off-white crystalline powder, soluble in organic solvents but less so in water. As with other benzodiazepines, it carries a risk of dependence and withdrawal symptoms, necessitating careful management in clinical use. Overall, ethyl loflazepate exemplifies the pharmacological characteristics typical of its class, providing both therapeutic benefits and potential risks.
Formula:C18H14ClFN2O3
InChI:InChI=1S/C18H14ClFN2O3/c1-2-25-18(24)16-17(23)21-14-8-7-10(19)9-12(14)15(22-16)11-5-3-4-6-13(11)20/h3-9,16H,2H2,1H3,(H,21,23)
InChI key:InChIKey=CUCHJCMWNFEYOM-UHFFFAOYSA-N
SMILES:FC1=C(C=2C=3C(NC(=O)C(C(OCC)=O)N2)=CC=C(Cl)C3)C=CC=C1
Synonyms:
  • 1H-1,4-Benzodiazepine-3-carboxylic acid, 7-chloro-5-(2-fluorophenyl)-2,3-dihydro-2-oxo-, ethyl ester
  • 1H-1,4-Benzodiazepine-3-carboxylic acid, 7-chloro-5-(o-fluorophenyl)-2,3-dihydro-2-oxo-, ethyl ester
  • Brn 0765264
  • Cm 6912
  • DEA No. 2758
  • Ethyl fluclozepate
  • Ethyl loflazepate
  • Ethyl loflazepate [INN:JAN]
  • Ethyl[7-chloro-5-(2-fluorophenyl)-2,3-dihydro-2-oxo-1H-1,4-benzodiazepine-3-carboxylate]
  • Ethylis loflazepas
  • See more synonyms
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Found 3 products.
  • Ethyl Loflazepate (1 mg/ml in Acetonitrile)
    TRC
    + Info

    Ethyl Loflazepate (1 mg/ml in Acetonitrile)

    Controlled Product
    CAS:
    Formula:C18H14ClFN2O3
    Color and Shape:Single Solution
    Molecular weight:360.77

    Ref: TR-KIT4600

    1x1ml
    1,048.00€
  • Ethyl Loflazepate
    TRC
    + Info

    Ethyl Loflazepate

    Controlled Product
    CAS:

    Applications A new benzodiazepine derivative as a new anti-anxiety drug. Ethyl Loflazepate and its metabolite were compared with those of Diazepam (D416855), Nitrazepam (N490140) and Lorazepam (L469850). The anticonflict effect of Ethyl Loflazepate was slightly more potent than that of Diazepam and much more potent than that of Lorazepam. Controlled substance.
    References Cano J.P., et al.: J. Chromatogr., 226, 413 (1981), Tanaka M., et al.: Clin. Neuropharmacology, (1985), 8,  271 (1985),

    Formula:C18H14ClFN2O3
    Color and Shape:White
    Molecular weight:360.77

    Ref: TR-E679525

    2500µg
    276.00€
    25mg
    1,685.00€
  • CymitQuimica logo
    Japanese Pharmacopoeia
    + Info

    Ethyl Loflazepate RS

    Controlled Product
    CAS:
    Color and Shape:White Solid Crystalline Powder

    Ref: 2K-1188800021

    100mg
    Discontinued
    Discontinued product