CAS 2920-86-7

Prednisolone 21-hemisuccinate

Description:

Prednisolone 21-hemisuccinate is a synthetic glucocorticoid derivative of prednisolone, primarily used for its anti-inflammatory and immunosuppressive properties. It is characterized by the presence of a hemisuccinate ester group at the 21 position of the prednisolone molecule, which enhances its solubility and bioavailability. This compound is typically administered in a pharmaceutical formulation, often as a sodium salt, to facilitate its use in various medical applications, particularly in treating conditions such as allergies, autoimmune disorders, and certain types of inflammation. Prednisolone 21-hemisuccinate exhibits a range of biological activities, including the modulation of immune responses and the inhibition of inflammatory pathways. Its pharmacokinetics involve absorption, metabolism, and excretion processes that are influenced by its chemical structure. As with other glucocorticoids, potential side effects may include alterations in glucose metabolism, increased susceptibility to infections, and other systemic effects, necessitating careful monitoring during therapeutic use.

Formula: C₂₅H₃₂O₈

InChI: InChI=1/C25H32O8/c1-23-9-7-15(26)11-14(23)3-4-16-17-8-10-25(32,24(17,2)12-18(27)22(16)23)19(28)13-33-21(31)6-5-20(29)30/h7,9,11,16-18,22,27,32H,3-6,8,10,12-13H2,1-2H3,(H,29,30)/t16?,17?,18-,22?,23-,24-,25-/m0/s1

InChI key: InChIKey=APGDTXUMTIZLCJ-CGVGKPPMSA-N

SMILES: C[C@@]12[C@]([C@]3([C@]([C@@H](O)C1)([C@]4(C)C(CC3)=CC(=O)C=C4)[H])[H])(CC[C@@]2(C(COC(CCC(O)=O)=O)=O)O)[H]

Synonyms:

• (11β)-21-(3-Carboxy-1-oxopropoxy)-11,17-dihydroxypregna-1,4-diene-3,20-dione
• 4-[(11,17-Dihydroxy-3,20-Dioxopregna-1,4-Dien-21-Yl)Oxy]-4-Oxobutanoic Acid
• 4-{[(11Beta)-11,17-Dihydroxy-3,20-Dioxopregna-1,4-Dien-21-Yl]Oxy}-4-Oxobutanoic Acid
• 4-{[(8Xi,9Xi,11Beta,14Xi)-11,17-Dihydroxy-3,20-Dioxopregna-1,4-Dien-21-Yl]Oxy}-4-Oxobutanoic Acid
• Prednisolone 21-(Hydrogen Succinate)
• Prednisolone 21-O-β-carbonylpropionic acid
• Prednisolone 21-succinate
• Prednisolone Succinate
• Prednisolone bisuccinate
• Prednisolone hemisuccinate
• Prednisolut
• Pregna-1,4-diene-3,20-dione, 11β,17,21-trihydroxy-, 21-(hydrogen succinate)
• Pregna-1,4-diene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-, (11β)-
• Δ¹-Hydrocortisone 21-hemisuccinate
• Δ1-Hydrocortisone 21-hemisuccinate
• Δ1-Hydrocortisone 21-hemisuccinate, 11β,17α,21-Trihydroxy-1,4-pregnadiene-3,20-dione 21-hemisuccinate, 1,4-Pregnadiene-11β,17,21-triol-3,20-dione 21-hemisuccinate
• Pregna-1,4-diene-3,20-dione, 11b,17,21-trihydroxy-, 21-(hydrogen succinate) (6CI, 7CI, 8CI)
• 1-DEHYDROCORTISOL 21-HEMISUCCINATE
• prednisolonbisuccinat
• prednisolone21-succinate
• 4-diene-3,20-dione,21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-pregna-(1
• prednisolonebisuccinate
• Pregna-1,4-diene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-, (11b)-(9CI)
• METACORTANDROLONE 21-HEMISUCCINATE
• 1,4-PREGNADIEN-11-BETA, 17,21-TRIOL-3,20-DIONE 21-HEMISUCCINATE
• 11-BETA,17-ALPHA,21-TRIHYDROXY-1,4-PREGNADIENE-3,20-DIONE 21-HEMISUCCINATE
• DELTA1-HYDROCORTISONE 21-HEMISUCCINATE
• 1,4-PREGNADIENE-11-BETA,17,21-TRIOL-3,20-DIONE 21-HEMISUCCINATE
• PREDNISOLONE 21-HEMISUCCINATE

Prednisolone Hemisuccinate

CAS: 2920-86-7

Color and Shape: White To Off-White

Ref: 61-FOR1559.00

Prednisolone Hemisuccinate

CAS: 2920-86-7

Adrenal cortical hormones and their derivatives nesoi

Formula: C₂₅H₃₂O₈

Color and Shape: Cream White Powder Clumpy Friable

Molecular weight: 460.20972

Ref: 45-1556507

Prednisolone (hemisuccinate)

CAS: 2920-86-7

Formula: C₂₅H₃₂O₈

Purity: 98%

Color and Shape: Solid

Molecular weight: 460.5168

Ref: IN-DA002XO6

Prednisolone Impurity 4 (Prednisolone Hemisuccinate)

CAS: 2920-86-7

Formula: C₂₅H₃₂O₈

Color and Shape: Off-White Solid

Molecular weight: 460.52

Ref: 4Z-P-111110

Prednisolone Hemisuccinate

Controlled Product

CAS: 2920-86-7

Formula: C₂₅H₃₂O₈

Color and Shape: Neat

Molecular weight: 460.52

Ref: 86-MM1559.00

Prednisolone Succinate RS

CAS: 2920-86-7

Color and Shape: White Solid Crystalline Powder

Ref: 2K-1137000021

Prednisolone Hemisuccinate-d8

Controlled Product

CAS: 2920-86-7

Formula: C₂₅D₈H₂₄O₈

Color and Shape: Neat

Molecular weight: 468.566

Ref: TR-P703762

Prednisolone 21-Hemisuccinate

Controlled Product

CAS: 2920-86-7

Prednisolone 21-hemisuccinate is a synthetic glucocorticoid that has antiinflammatory activity. Prednisolone 21-Hemisuccinate is used in the treatment of inflammatory bowel disease, as well as various other types of inflammatory conditions, such as autoimmune diseases and infectious diseases. It is also used to treat myocardial infarcts and various types of cancer (e.g., leukemia). Prednisolone 21-hemisuccinate acts by binding to the glucocorticoid receptor, which alters gene expression and protein synthesis in cells. Prednisolone 21-Hemisuccinate binds to the Toll-like receptor 4 (TLR4), thereby inhibiting inflammation in mouse models of colitis. Prednisolone 21-Hemisuccinate also decreases glucose levels by decreasing insulin secretion from pancreatic beta cells.

Purity: Min. 95%

Ref: 3D-FP41786

Prednisolone hemisuccinate

CAS: 2920-86-7

Prednisolone hemisuccinate is a soluble glucocorticoid and cortisol exerts anti-inflammatory, immunosuppressive, and antiallergic by binding to GR receptor.

Formula: C₂₅H₃₂O₈

Purity: 99.96%

Color and Shape: Solid

Molecular weight: 460.52

Ref: TM-T13825

Methylprednisolone hydrogen succinate EP Impurity E

CAS: 2920-86-7

Formula: C₂₅H₃₂O₈

Molecular weight: 460.5

Ref: ST-EA-CP-M14057