CAS 2920-86-7: Prednisolone 21-hemisuccinate
Description:Prednisolone 21-hemisuccinate is a synthetic glucocorticoid derivative of prednisolone, primarily used for its anti-inflammatory and immunosuppressive properties. It is characterized by the presence of a hemisuccinate ester group at the 21 position of the prednisolone molecule, which enhances its solubility and bioavailability. This compound is typically administered in a pharmaceutical formulation, often as a sodium salt, to facilitate its use in various medical applications, particularly in treating conditions such as allergies, autoimmune disorders, and certain types of inflammation. Prednisolone 21-hemisuccinate exhibits a range of biological activities, including the modulation of immune responses and the inhibition of inflammatory pathways. Its pharmacokinetics involve absorption, metabolism, and excretion processes that are influenced by its chemical structure. As with other glucocorticoids, potential side effects may include alterations in glucose metabolism, increased susceptibility to infections, and other systemic effects, necessitating careful monitoring during therapeutic use.
Formula:C25H32O8
InChI:InChI=1S/C25H32O8/c1-23-9-7-15(26)11-14(23)3-4-16-17-8-10-25(32,24(17,2)12-18(27)22(16)23)19(28)13-33-21(31)6-5-20(29)30/h7,9,11,16-18,22,27,32H,3-6,8,10,12-13H2,1-2H3,(H,29,30)/t16-,17-,18-,22+,23-,24-,25-/m0/s1
InChI key:InChIKey=APGDTXUMTIZLCJ-CGVGKPPMSA-N
SMILES:O=C1C=CC2(C(=C1)CCC3C4CCC(O)(C(=O)COC(=O)CCC(=O)O)C4(C)CC(O)C32)C
- Synonyms:
- (11β)-21-(3-Carboxy-1-oxopropoxy)-11,17-dihydroxypregna-1,4-diene-3,20-dione
- 4-[(11,17-Dihydroxy-3,20-Dioxopregna-1,4-Dien-21-Yl)Oxy]-4-Oxobutanoic Acid
- 4-{[(11Beta)-11,17-Dihydroxy-3,20-Dioxopregna-1,4-Dien-21-Yl]Oxy}-4-Oxobutanoic Acid
- 4-{[(8Xi,9Xi,11Beta,14Xi)-11,17-Dihydroxy-3,20-Dioxopregna-1,4-Dien-21-Yl]Oxy}-4-Oxobutanoic Acid
- Prednisolone 21-(Hydrogen Succinate)
- Prednisolone 21-O-β-carbonylpropionic acid
- Prednisolone 21-succinate
- Prednisolone Succinate
- Prednisolone bisuccinate
- Prednisolone hemisuccinate
- See more synonyms
- Prednisolut
- Pregna-1,4-diene-3,20-dione, 11β,17,21-trihydroxy-, 21-(hydrogen succinate)
- Pregna-1,4-diene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-, (11β)-
- Δ<sup>1</sup>-Hydrocortisone 21-hemisuccinate
- Δ1-Hydrocortisone 21-hemisuccinate
