CAS 2922402-03-5

EGFR kinase inhibitor 3

Formula: C₃₁H₂₅N₇O₃S

Synonyms:

• EGFR kinase inhibitor 3

EGFR kinase inhibitor 3

CAS: 2922402-03-5

EGFR kinase inhibitor 3 (compound 2) serves as a dual-action inhibitor targeting both ATP and allosteric sites of the EGFR kinase, exhibiting potent IC50 values of less than 10 nM for wild-type EGFR, 1.5 nM for the L858R mutation, 0.059 nM for the L858R/T790M mutation, and 0.064 nM for the L858R/T790M/C797S mutation. It is classified as a C-linked inhibitor [1].

Formula: C₃₁H₂₅N₇O₃S

Molecular weight: 575.64

Ref: TM-T86341