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CAS 2922814-85-3

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  • NLRP3-IN-81
    Targetmol
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    NLRP3-IN-81

    CAS:
    NLRP3-IN-81 (N102) is an inhibitor capable of crossing the blood-brain barrier, effectively countering NLRP3 inflammasome-dependent pyroptosis with an EC50 of 0.029 μM for Nigericin-induced pyroptosis. It significantly suppresses caspase-1 activation and IL-1β release that depend on NLRP3. Additionally, NLRP3-IN-81 disrupts the interaction between NLRP3 and the adaptor protein ASC, while inhibiting ASC oligomerization. This compound is applicable in research on pyroptosis-related diseases, such as inflammatory bowel disease and type 2 diabetes.
    Formula:C16H15F3N2O3S
    Color and Shape:Solid
    Molecular weight:372.36

    Ref: TM-T210731