CAS 2924835-36-7

Pomalidomide-amino-PEG4-C4-Cl

Description:

Pomalidomide-amino-PEG4-C4-Cl is a synthetic compound that combines elements of pomalidomide, a well-known immunomodulatory drug, with a polyethylene glycol (PEG) linker and a chlorinated moiety. The presence of the PEG4 segment enhances the solubility and bioavailability of the compound, facilitating its use in various biomedical applications. The amino group allows for further functionalization, making it versatile for conjugation with other molecules, such as targeting agents or therapeutic agents. The chlorinated carbon chain (C4-Cl) may influence the compound's hydrophobicity and interaction with biological membranes. Overall, this compound is likely to exhibit properties that are beneficial for drug delivery systems, particularly in targeted therapies for conditions like cancer, where pomalidomide is already utilized. Its design aims to improve pharmacokinetics and therapeutic efficacy while minimizing side effects. As with any chemical substance, its safety, stability, and reactivity should be thoroughly evaluated in the context of its intended applications.

Synonyms:

• Pomalidomide-amino-PEG4-C4-Cl

Pomalidomide-amino-PEG4-C4-Cl

CAS: 2924835-36-7

Pomalidomide-amino-PEG4-C4-Cl (Intermediate 4d) is an E3 ligase ligand-linker conjugate featuring a Pomalidomide-based cereblon (CRBN) ligand and a linker. This compound is utilized in the synthesis of PROTACs.

Formula: C₂₇H₃₆ClN₃O₉

Molecular weight: 582.04

Ref: TM-T208313