CAS 292618-32-7: Gimatecan

Description: Gimatecan is a synthetic compound classified as a topoisomerase I inhibitor, primarily investigated for its potential use in cancer therapy. It is a derivative of camptothecin, a natural alkaloid known for its anticancer properties. Gimatecan exhibits a mechanism of action that involves the stabilization of the topoisomerase I-DNA complex, leading to DNA damage and subsequent cell death, particularly in rapidly dividing cancer cells. The compound is characterized by its ability to penetrate cellular membranes effectively, which enhances its therapeutic potential. Additionally, Gimatecan has been studied for its pharmacokinetic properties, including its absorption, distribution, metabolism, and excretion, which are crucial for determining its efficacy and safety profile in clinical settings. Its chemical structure includes a lactone ring, which is essential for its biological activity. Ongoing research aims to optimize its formulation and delivery to improve its effectiveness against various malignancies while minimizing side effects.

Formula: C₂₅H₂₅N₃O₅

InChI: InChI=1S/C25H25N3O5/c1-5-25(31)18-10-20-21-16(12-28(20)22(29)17(18)13-32-23(25)30)15(11-26-33-24(2,3)4)14-8-6-7-9-19(14)27-21/h6-11,31H,5,12-13H2,1-4H3/b26-11+/t25-/m0/s1

InChI key: InChIKey=UIVFUQKYVFCEKJ-OPTOVBNMSA-N

SMILES: O=C1OCC=2C(=O)N3C(=CC2C1(O)CC)C=4N=C5C=CC=CC5=C(C=NOC(C)(C)C)C4C3

Synonyms:

• Gimatecan
• 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-11-carboxaldehyde, 4-ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-, 11-[O-(1,1-dimethylethyl)oxime], [C(E),4S]-
• (S)-Gimatecan
• 7-[(E)-t-Butyloxyiminomethyl]camptothecin
• ST 1481

1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-11-carboxaldehyde, 4-ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-, 11-[O-(1,1-dimethylethyl)oxime], [C(E),4S]-

CAS: 292618-32-7

• Formula: C₂₅H₂₅N₃O₅
• Purity: 99.28%
• Molecular weight: 447.4831

Gimatecan

CAS: 292618-32-7

• Purity: 98.47%
• Molecular weight: 447.48g/mol

Gimatecan

CAS: 292618-32-7

Please enquire for more information about Gimatecan including the price, delivery time and more detailed …

• Formula: C₂₅H₂₅N₃O₅
• Purity: Min. 95%
• Molecular weight: 447.5 g/mol

Gimatecan

CAS: 292618-32-7

Gimatecan (STI481) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue …

• Formula: C₂₅H₂₅N₃O₅
• Purity: 98.47%
• Color and Shape: Solid
• Molecular weight: 447.48