CAS 292618-32-7

Gimatecan

Description:

Gimatecan is a synthetic compound classified as a topoisomerase I inhibitor, primarily investigated for its potential use in cancer therapy. It is a derivative of camptothecin, a natural alkaloid known for its anticancer properties. Gimatecan exhibits a mechanism of action that involves the stabilization of the topoisomerase I-DNA complex, leading to DNA damage and subsequent cell death, particularly in rapidly dividing cancer cells. The compound is characterized by its ability to penetrate cellular membranes effectively, which enhances its therapeutic potential. Additionally, Gimatecan has been studied for its pharmacokinetic properties, including its absorption, distribution, metabolism, and excretion, which are crucial for determining its efficacy and safety profile in clinical settings. Its chemical structure includes a lactone ring, which is essential for its biological activity. Ongoing research aims to optimize its formulation and delivery to improve its effectiveness against various malignancies while minimizing side effects.

Formula: C₂₅H₂₅N₃O₅

InChI: InChI=1S/C25H25N3O5/c1-5-25(31)18-10-20-21-16(12-28(20)22(29)17(18)13-32-23(25)30)15(11-26-33-24(2,3)4)14-8-6-7-9-19(14)27-21/h6-11,31H,5,12-13H2,1-4H3/b26-11+/t25-/m0/s1

InChI key: InChIKey=UIVFUQKYVFCEKJ-OPTOVBNMSA-N

SMILES: C(=N/OC(C)(C)C)\C1=C2C(C=3N(C2)C(=O)C4=C(C3)[C@](CC)(O)C(=O)OC4)=NC=5C1=CC=CC5

Synonyms:

• Gimatecan
• 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-11-carboxaldehyde, 4-ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-, 11-[O-(1,1-dimethylethyl)oxime], [C(E),4S]-
• (S)-Gimatecan
• 7-[(E)-t-Butyloxyiminomethyl]camptothecin
• ST 1481

1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-11-carboxaldehyde, 4-ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-, 11-[O-(1,1-dimethylethyl)oxime], [C(E),4S]-

CAS: 292618-32-7

Formula: C₂₅H₂₅N₃O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 447.4831

Ref: IN-DA002XVK

Gimatecan

CAS: 292618-32-7

Gimatecan

Purity: ≥98%

Molecular weight: 447.48g/mol

Ref: 54-BUP00513

Gimatecan

CAS: 292618-32-7

Gimatecan (STI481) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity.

Formula: C₂₅H₂₅N₃O₅

Purity: 98.47%

Color and Shape: Solid

Molecular weight: 447.48

Ref: TM-T21319

Gimatecan

CAS: 292618-32-7

Gimatecan is a cycle-specific inhibitor that targets kinases and proteins involved in cancer cell growth. It is a medicinal compound that has been shown to be effective against various types of human cancers. Gimatecan works by inhibiting the activity of protein kinases, which are enzymes that promote cell division and proliferation. This inhibition leads to apoptosis, or programmed cell death, in tumor cells. Gimatecan has been tested extensively in Chinese hamster ovary cells and has demonstrated potent anticancer activity. The compound is excreted primarily through urine and has shown promising results as an anticancer agent in preclinical studies.

Formula: C₂₅H₂₅N₃O₅

Purity: Min. 95%

Molecular weight: 447.5 g/mol

Ref: 3D-SLA61832