CAS 292633-16-0

Ac-Leu-Glu-His-Asp-AMC

Description:

Ac-Leu-Glu-His-Asp-AMC, with the CAS number 292633-16-0, is a synthetic peptide that serves as a substrate for various proteolytic enzymes, particularly in biochemical research and assays. This compound is characterized by its sequence of amino acids: acetylated leucine (Ac-Leu), glutamic acid (Glu), histidine (His), aspartic acid (Asp), followed by the fluorogenic moiety AMC (7-amino-4-methylcoumarin). The acetylation at the N-terminus enhances its stability and solubility, while the AMC group allows for fluorescence detection upon cleavage by enzymes, making it useful in studying protease activity. The peptide's structure contributes to its specificity and reactivity, enabling researchers to investigate enzyme kinetics and mechanisms in various biological contexts. Additionally, the presence of charged and polar side chains in the amino acids influences its interactions in solution, affecting its overall behavior in biochemical assays.

Formula: C₃₃H₄₁N₇O₁₁

Synonyms:

• L-a-Asparagine, N-acetyl-L-leucyl-L-a-glutamyl-L-histidyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-

N-Acetyl-Leu-Glu-His-Asp-7-amino-4-methylcoumarin

CAS: 292633-16-0

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₃₃H₄₁N₇O₁₁

Molecular weight: 711.72

Ref: 02-J66335

Ac-LEHD-AMC

CAS: 292633-16-0

Ac-LEHD-AMC, a fluorogenic caspase-9 substrate, releases fluorescent AMC upon cleavage, aiding caspase-9 activity measurement.

Formula: C₃₃H₄₁N₇O₁₁

Color and Shape: Solid

Molecular weight: 711.729

Ref: TM-T36342

Ac-Leu-Glu-His-Asp-MCA

CAS: 292633-16-0

Ac-Leu-Glu-His-Asp-MCA is a synthetic peptide that is used as a research tool. The peptide has been shown to bind to the alpha subunit of the nicotinic acetylcholine receptor, which is responsible for binding acetylcholine and transmitting nerve impulses. Ac-Leu-Glu-His-Asp-MCA activates the receptor by mimicking the effects of acetylcholine. Acetylcholine binding to the alpha subunit causes an influx of sodium ions into the cell, which leads to depolarization and an action potential. This synthetic peptide also binds to other types of receptors, including those for serotonin, dopamine, and adrenaline. Acetylcholine binding to these receptors leads to neurotransmitter release.

Formula: C₃₃H₄₁N₇O₁₁

Purity: Min. 95%

Molecular weight: 711.72 g/mol

Ref: 3D-MCA-3198-V

Ac-Leu-Glu-His-Asp-AMC trifluoroacetate salt

CAS: 292633-16-0

Ac-Leu-Glu-His-Asp-AMC trifluoroacetate salt is a synthetic peptide that is derived from the amino acid sequence of caspases. Ac-Leu-Glu-His-Asp-AMC trifluoroacetate salt induces apoptosis in insect and E. coli cells by protease activity, which leads to cell death. The sequence of this peptide is found in Drosophila melanogaster and has been shown to induce apoptosis in insect cells. Caspases are enzymes that regulate apoptosis and play a key role in cell death.

Formula: C₃₃H₄₁N₇O₁₁

Purity: Min. 95%

Molecular weight: 711.72 g/mol

Ref: 3D-FA110585