CAS 292634-27-6

Dianicline

Description:

Dianicline is a chemical compound that acts as a selective agonist for nicotinic acetylcholine receptors, particularly the α4β2 subtype. It is primarily investigated for its potential use in smoking cessation therapies due to its ability to modulate nicotine's effects on the brain. The compound is characterized by its ability to enhance dopaminergic activity, which may help alleviate withdrawal symptoms associated with nicotine dependence. Dianicline has a relatively complex molecular structure, which contributes to its pharmacological properties. Its efficacy and safety profile have been the subject of various studies, focusing on its potential therapeutic applications and side effects. As with many compounds targeting neurotransmitter systems, understanding its pharmacokinetics, including absorption, distribution, metabolism, and excretion, is crucial for evaluating its clinical utility. Overall, Dianicline represents a significant area of research in the field of neuropharmacology, particularly in the context of addiction and smoking cessation strategies.

Formula: C₁₃H₁₆N₂O

InChI: InChI=1S/C13H16N2O/c1-2-11-10(14-5-1)8-13-4-7-15(9-13)6-3-12(13)16-11/h1-2,5,12H,3-4,6-9H2/t12-,13+/m0/s1

InChI key: InChIKey=SUPRUPHAEXPGPF-QWHCGFSZSA-N

SMILES: [C@@]123[C@@](OC=4C(C1)=NC=CC4)(CC[N@@](C2)CC3)[H]

Synonyms:

• (5aS,8S,10aR)-5a,6,9,10-Tetrahydro-7H,11H-8,10a-methanopyrido[2′,3′:5,6]pyrano[2,3-d]azepine
• 7H,11H-8,10a-Methanopyrido[2′,3′:5,6]pyrano[2,3-d]azepine, 5a,6,9,10-tetrahydro-, (5aS,8S,10aR)-
• Dianicline
• Ssr 591813

Dianicline dihydrochloride

CAS: 292634-27-6

Dianicline dihydrochloride is a partial agonist of α4β2 nicotinic acetylcholine receptor. It increases cessation rates in a dose-dependent manner.

Formula: C₁₃H₁₆N₂O

Purity: 98%

Color and Shape: Solid

Molecular weight: 216.28

Ref: TM-T15112

Dianicline

CAS: 292634-27-6

Dianicline is a dopaminergic agent that has been used in the treatment of Parkinson's disease. It is a nicotinic acetylcholine receptor agonist with cholinergic properties. This drug binds to the α7 nicotinic acetylcholine receptors, which are located on postsynaptic neurons, and increases dopamine release from the presynaptic terminal by inhibiting the reuptake of dopamine into the presynaptic neuron. It also acts as a receptor antagonist for cholinergic receptors of muscarinic type M1 and M2. The primary analysis of dianicline showed that it was more effective than placebo in treating Parkinson's disease symptoms, such as tremors and muscular rigidity. Clinical studies have shown that this drug may be beneficial for patients with early-stage Parkinson's disease who have not responded to levodopa therapy. Dianicline is metabolized by CYP2D6, which may lead to drug interactions with other drugs that are metabol

Formula: C₁₃H₁₆N₂O

Purity: Min. 95%

Molecular weight: 216.28 g/mol

Ref: 3D-SLA63427