WEE1-IN-6 is a small molecule inhibitor that targets the WEE1 kinase, an important regulator of the cell cycle, particularly in the context of DNA damage response and repair mechanisms. By inhibiting WEE1, this compound can disrupt the cell cycle, leading to enhanced sensitivity of cancer cells to DNA-damaging agents, such as radiation and certain chemotherapeutics. The compound is characterized by its ability to selectively inhibit WEE1 activity, which can result in the promotion of cell cycle progression despite the presence of DNA damage. This mechanism makes WEE1-IN-6 a potential candidate for combination therapies in oncology, particularly for tumors that exhibit resistance to conventional treatments. In terms of its chemical properties, WEE1-IN-6 is typically evaluated for its solubility, stability, and bioavailability, which are crucial for its efficacy as a therapeutic agent. As research continues, the pharmacokinetics and pharmacodynamics of WEE1-IN-6 are also being studied to better understand its potential applications in cancer treatment.

WEE1-IN-6

2928524-08-5: WEE1-IN-6 is a small molecule inhibitor that targets the WEE1 kinase, an important regulator of the cell cycle, particularly in the context of DNA damage response and repair mechanisms. By inhibiting WEE1, this compound can disrupt the cell cycle, leading to enhanced sensitivity of cancer cells to DNA-damaging agents, such as radiation and certain chemotherapeutics. The compound is characterized by its ability to selectively inhibit WEE1 activity, which can result in the promotion of cell cycle progression despite the presence of DNA damage. This mechanism makes WEE1-IN-6 a potential candidate for combination therapies in oncology, particularly for tumors that exhibit resistance to conventional treatments. In terms of its chemical properties, WEE1-IN-6 is typically evaluated for its solubility, stability, and bioavailability, which are crucial for its efficacy as a therapeutic agent. As research continues, the pharmacokinetics and pharmacodynamics of WEE1-IN-6 are also being studied to better understand its potential applications in cancer treatment.

<p>WEE1-IN-6 (compound 110) is an orally active inhibitor of WEE1, displaying a DC50 value of ≤ 100 nM. This compound effectively inhibits cell proliferation [1].</p>

CAS 2928524-08-5

WEE1-IN-6

WEE1-IN-6

Ref: TM-T87631