P5(PEG24)-VC-PAB-exatecan is a complex chemical compound that belongs to the class of drug conjugates, specifically designed for targeted cancer therapy. This substance features a polymeric backbone, typically composed of polyethylene glycol (PEG), which enhances solubility and biocompatibility. The "P5" designation suggests a pentavalent structure, indicating multiple functional groups or active sites that can interact with biological targets. The "VC" refers to a valine-citrulline linker, which is often used to facilitate the release of the active drug component upon cellular uptake. "PAB" denotes a p-aminobenzyl moiety, which can play a role in the stability and efficacy of the conjugate. Exatecan, the active drug component, is a potent topoisomerase inhibitor, which disrupts DNA replication in cancer cells. Overall, this compound is engineered to improve the therapeutic index of exatecan by selectively delivering it to tumor cells while minimizing systemic toxicity, making it a promising candidate in the field of targeted cancer therapies.

P5(PEG24)-VC-PAB-exatecan

2928571-43-9: P5(PEG24)-VC-PAB-exatecan is a complex chemical compound that belongs to the class of drug conjugates, specifically designed for targeted cancer therapy. This substance features a polymeric backbone, typically composed of polyethylene glycol (PEG), which enhances solubility and biocompatibility. The "P5" designation suggests a pentavalent structure, indicating multiple functional groups or active sites that can interact with biological targets. The "VC" refers to a valine-citrulline linker, which is often used to facilitate the release of the active drug component upon cellular uptake. "PAB" denotes a p-aminobenzyl moiety, which can play a role in the stability and efficacy of the conjugate. Exatecan, the active drug component, is a potent topoisomerase inhibitor, which disrupts DNA replication in cancer cells. Overall, this compound is engineered to improve the therapeutic index of exatecan by selectively delivering it to tumor cells while minimizing systemic toxicity, making it a promising candidate in the field of targeted cancer therapies.

P5(PEG24)-VC-PAB-exatecan, a camptothecin-based linker-payload platform, utilizes the highly potent derivative exatecan. This compound features linker-payload structures and is primarily employed in the research of tumor [1].

CAS 2928571-43-9

P5(PEG24)-VC-PAB-exatecan

P5(PEG24)-VC-PAB-exatecan

Ref: TM-T87839