CAS 2933-94-0

Toliprolol

Description:

Toliprolol is a beta-adrenergic antagonist, primarily used in the treatment of hypertension and certain heart conditions. It is characterized by its ability to selectively block beta-1 adrenergic receptors, which are primarily found in the heart, leading to a decrease in heart rate and myocardial contractility. This selective action helps minimize side effects commonly associated with non-selective beta-blockers. Toliprolol is typically administered orally and is known for its relatively long half-life, allowing for once-daily dosing in many cases. The compound is soluble in water, which facilitates its absorption in the gastrointestinal tract. Additionally, it exhibits a favorable pharmacokinetic profile, with a predictable metabolism and excretion pathway. As with other beta-blockers, potential side effects may include fatigue, dizziness, and bradycardia, and it should be used cautiously in patients with respiratory conditions due to the risk of bronchoconstriction. Overall, Toliprolol represents a valuable option in cardiovascular pharmacotherapy, particularly for patients requiring beta-blockade with a focus on heart rate control.

Formula: C₁₃H₂₁NO₂

InChI: InChI=1S/C13H21NO2/c1-10(2)14-8-12(15)9-16-13-6-4-5-11(3)7-13/h4-7,10,12,14-15H,8-9H2,1-3H3

InChI key: InChIKey=NXQMNKUGGYNLBY-UHFFFAOYSA-N

SMILES: O(CC(CNC(C)C)O)C1=CC(C)=CC=C1

Synonyms:

• 1-(3-Methylphenoxy)-2-hydroxy-3-(isopropylamino)propane
• 1-(3-Methylphenoxy)-3-(Propan-2-Ylamino)Propan-2-Ol
• 1-(3-Methylphenoxy)-3-(isopropylamino)-2-propanol
• 1-(3-Methylphenoxy)-3-[(propan-2-yl)amino]propan-2-ol
• 1-(3-Tolyloxy)-3-isopropylamino-2-propanol
• 1-(Isopropylamino)-3-(m-tolyloxy)-2-propanol
• 1-(m-Tolyloxy)-2-hydroxy-3-(isopropylamino)propane
• 1-[(1-Methylethyl)amino]-3-(3-methylphenoxy)-2-propanol
• 2-Propanol, 1-((1-methylethyl)amino)-3-(3-methylphenoxy)- (9CI)
• 2-Propanol, 1-(isopropylamino)-3-(m-tolyloxy)-
• 2-Propanol, 1-[(1-methylethyl)amino]-3-(3-methylphenoxy)-
• 3-(3-Methylphenoxy)-1-(isopropylamino)-2-propanol
• Brn 1874722
• Isopropylamino-1-m-tolyloxy-3-propan-2-ol
• Isopropylamino-1-m-tolyloxy-3-propan-2-ol [German]
• Mhip
• Racemic Toliprolol
• Toliprolol [INN]
• Toliprololum
• Toliprololum [INN-Latin]
• Unii-Dcp58J201D
• [2-Hydroxy-3-(3-methylphenoxy)propyl](propan-2-yl)amine

Toliprolol

CAS: 2933-94-0

Toliprolol is an adrenergic receptor antagonist with some stimulant action; it has been proposed for angina pectoris.

Formula: C₁₃H₂₁NO₂

Color and Shape: Solid

Molecular weight: 223.31

Ref: TM-T69494