Boc-Asp(OtBu)-ONp, also known as N-tert-butoxycarbonyl-L-aspartic acid 2-nitrophenyl ester, is a chemical compound commonly used in peptide synthesis and biochemistry. It features a tert-butoxycarbonyl (Boc) protecting group on the amino group of aspartic acid, which helps to prevent unwanted reactions during synthesis. The presence of the 2-nitrophenyl (ONp) ester group serves as a leaving group, facilitating the coupling of aspartic acid in peptide formation. This compound is typically a white to off-white solid and is soluble in organic solvents such as dichloromethane and dimethylformamide, but less soluble in water. Its stability under standard laboratory conditions makes it a valuable intermediate in the synthesis of peptides and other bioactive molecules. The compound's reactivity can be influenced by factors such as pH and the presence of nucleophiles, which are important considerations in synthetic applications. Overall, Boc-Asp(OtBu)-ONp is a versatile reagent in organic and medicinal chemistry, particularly in the context of peptide synthesis.

Boc-Asp(OtBu)-ONp

29365-05-7: Boc-Asp(OtBu)-ONp, also known as N-tert-butoxycarbonyl-L-aspartic acid 2-nitrophenyl ester, is a chemical compound commonly used in peptide synthesis and biochemistry. It features a tert-butoxycarbonyl (Boc) protecting group on the amino group of aspartic acid, which helps to prevent unwanted reactions during synthesis. The presence of the 2-nitrophenyl (ONp) ester group serves as a leaving group, facilitating the coupling of aspartic acid in peptide formation. This compound is typically a white to off-white solid and is soluble in organic solvents such as dichloromethane and dimethylformamide, but less soluble in water. Its stability under standard laboratory conditions makes it a valuable intermediate in the synthesis of peptides and other bioactive molecules. The compound's reactivity can be influenced by factors such as pH and the presence of nucleophiles, which are important considerations in synthetic applications. Overall, Boc-Asp(OtBu)-ONp is a versatile reagent in organic and medicinal chemistry, particularly in the context of peptide synthesis.

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CAS 29365-05-7

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