CAS 2937327-83-6

(S)-2-Amino-4-methyl-4-(3-(2-((S)-2-methyl-1,4-diazepan-1-yl)pyrimidin-4-yl)-1,2,4-oxadiazol-5-yl)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile

CAS: 2937327-83-6

(S)-2-Amino-4-methyl-4-(3-(2-((S)-2-methyl-1,4-diazepan-1-yl)pyrimidin-4-yl)-1,2,4-oxadiazol-5-yl)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile

Purity: 95%

Molecular weight: 450.57g/mol

Ref: 54-OR1075069

pan-KRAS degrader 1

CAS: 2937327-83-6

Pan-KRAS degrader 1 (Compound 1) is a broad-spectrum KRAS degrader, exhibiting an inhibitory constant Ki value of 25 nM against KRASG12V as determined by surface plasmon resonance (SPR). Additionally, this compound demonstrates antitumor activity.

Formula: C₂₂H₂₆N₈OS

Color and Shape: Solid

Molecular weight: 450.56

Ref: TM-T200566