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CAS 2940242-88-4

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  • YB-3-17
    Targetmol
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    YB-3-17

    CAS:
    <p>YB-3-17 is a bifunctional molecule that can inhibit mTOR with an IC50 of 0.22 nM or degrade the G1 to S phase transition 1 gene (GSPT1) through the PROTAC mechanism, with a DC50 of 5 nM. It exhibits antiproliferative activity at nanomolar concentrations in various glioblastoma cell lines. Additionally, YB-3-17 shows antitumor activity in mouse models. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligase Cereblon)</p>
    Formula:C38H39N11O6
    Color and Shape:Solid
    Molecular weight:745.786

    Ref: TM-T204111