CAS 2941088-96-4

WH244

Synonyms:

• WH244

WH244

CAS: 2941088-96-4

WH244 is a second-generation dual degrader (PROTAC) targeting BCL-2 and BCL-xL proteins. It effectively degrades these proteins with high specificity, exhibiting a DC50 of 0.6 nM for BCL-xL and 7.4 nM for BCL-2. By promoting ubiquitination and subsequent proteasomal degradation of these proteins, WH244 restores apoptotic pathways in cells. The compound shows strong antitumor activity.

Formula: C₈₃H₁₀₅ClF₃N₁₃O₁₁S₄

Color and Shape: Solid

Molecular weight: 1681.51

Ref: TM-T88099