CAS 29457-07-6

Ticarcillin disodium

Description:

Ticarcillin disodium is a semisynthetic penicillin antibiotic that is primarily used to treat infections caused by susceptible Gram-negative bacteria. It is characterized by its broad-spectrum activity, particularly against Pseudomonas aeruginosa and other Enterobacteriaceae. The compound is a disodium salt of ticarcillin, which enhances its solubility in aqueous solutions, making it suitable for intravenous administration. Ticarcillin works by inhibiting bacterial cell wall synthesis, leading to cell lysis and death. It is often used in combination with other antibiotics, such as clavulanic acid, to overcome resistance mechanisms. The substance is typically administered in a clinical setting, and its pharmacokinetics include rapid distribution in body tissues, with renal excretion being the primary route of elimination. Common side effects may include allergic reactions, gastrointestinal disturbances, and alterations in blood coagulation. As with all antibiotics, appropriate susceptibility testing is recommended to ensure effectiveness against specific pathogens.

Formula: C₁₅H₁₆N₂O₆S₂·2Na

InChI: InChI=1S/C15H16N2O6S2.2Na/c1-15(2)9(14(22)23)17-11(19)8(12(17)25-15)16-10(18)7(13(20)21)6-3-4-24-5-6;;/h3-5,7-9,12H,1-2H3,(H,16,18)(H,20,21)(H,22,23);;/t7-,8-,9+,12-;;/m1../s1

InChI key: InChIKey=IPRJTUDVZGEREZ-QBGWIPKPSA-N

SMILES: N(C([C@H](C(O)=O)C=1C=CSC1)=O)[C@H]2[C@@]3(N([C@@H](C(O)=O)C(C)(C)S3)C2=O)[H].[Na]

Synonyms:

• 3-Thiophenemalonamic acid, N-(2-carboxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-6-yl)-, disodium salt, <span class="text-smallcaps">D</span>-(-)-
• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[(carboxy-3-thienylacetyl)amino]-3,3-dimethyl-7-oxo-, disodium salt, [2S-[2α,5α,6β(S*)]]-
• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2R)-2-carboxy-2-(3-thienyl)acetyl]amino]-3,3-dimethyl-7-oxo-, sodium salt (1:2), (2S,5R,6R)-
• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2R)-carboxy-3-thienylacetyl]amino]-3,3-dimethyl-7-oxo-, disodium salt, (2S,5R,6R)-
• 6-<span class="text-smallcaps">D</span>(-)-(α-Carboxy-3-thienylacetamido)penicillanic acid disodium salt
• 6-<span class="text-smallcaps">D</span>-(-)-α-Carboxy-3-thienylmethylacetamido penicillanic acid
• Ab 2288
• Brl 2288
• Disodium ticarcillin
• Monapen
• Ticar
• Ticarcillin Disodium
• Ticarcillin disodium salt
• Ticarcillin sodium
• Ticarcillin sodium salt
• Ticarpen
• disodium (2R,5R,6R)-6-{[carboxylato(thiophen-3-yl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
• disodium (2S,5R,6R)-6-{[(2R)-2-carboxylato-2-thiophen-3-ylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
• α-Carboxy-3-thienylmethylpenicillin disodium salt
• 3-Thiophenemalonamic acid, N-(2-carboxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-6-yl)-, disodium salt, D-(-)-

Ticarcillin sodium

CAS: 29457-07-6

Ticarcillin sodium

Purity: ≥95%

Molecular weight: 430.41g/mol

Ref: 54-BUP16405

Ticarcillin sodium

CAS: 29457-07-6

Ticarcillin sodium: a semisynthetic, broad-spectrum antibiotic effective against various aerobic and anaerobic bacteria.

Formula: C₁₅H₁₆N₂O₆S₂·2Na

Purity: 99.09%

Color and Shape: Solid

Molecular weight: 430.41

Ref: TM-T6706

Ticarcillin Disodium Salt (Contain 10% Methanol)

Controlled Product

CAS: 29457-07-6

Stability Hygroscopic
Applications The disodium salt of Ticarcillin, a carboxypenicillin belonging to the beta-lactam class of antibiotics. Ticarcillin is an injectable antibiotic used in the treatment of infections caused by gram-negative bacteria, particularly Pseudomonas aeruginosa.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Paisley, J.W. et al.: Antimicrob. Agents Chemother., 14, 224 (1978); Fass, R.J. et al.: Rev. Infect. Dis., 2, 841 (1980); Husson, M.O. et al.: Drugs Exp. Clin. Res., 9, 843 (1983);

Formula: C₁₅H₁₄N₂O₆S₂·2Na

Color and Shape: Neat

Molecular weight: 428.39

Ref: TR-T437901

Ticarcillin disodium

CAS: 29457-07-6

Ticarcillin is a bactericidal antibiotic that is used to treat many types of infections caused by gram-positive bacteria, such as Streptococcus pneumoniae, Enterococcus faecalis and Enterococcus faecium. Ticarcillin has been shown to be effective against antibiotic-resistant strains of bacteria, including multidrug efflux pumps. This drug also has been shown to inhibit the growth of gram-negative bacteria such as Escherichia coli and Pseudomonas aeruginosa. Ticarcillin is used in combination with clavulanic acid for the treatment of infections caused by beta-lactamase producing organisms. It is also used in wastewater treatment to inhibit the growth of gram-negative bacteria that are resistant to other antibiotics. Ticarcillin can interfere with other medications by inhibiting their metabolism through cytochrome P450 enzymes or through competition for protein binding sites.

Formula: C₁₅H₁₆N₂Na₂O₆S₂

Purity: Min. 80.0 Area-%

Color and Shape: White Powder

Molecular weight: 430.41 g/mol

Ref: 3D-FC75007

Ticarcillin Disodium Salt-13C3 (Contain 10% Methanol)

Controlled Product

CAS: 29457-07-6

Formula: C₃C₁₂H₁₄N₂Na₂O₆S₂

Color and Shape: Neat

Molecular weight: 431.369

Ref: TR-T437902