CAS 29608-49-9

Almitrine bismesylate

Description:

Almitrine bismesylate is a chemical compound primarily known for its use in the treatment of respiratory disorders, particularly in enhancing oxygenation in patients with chronic obstructive pulmonary disease (COPD). It is classified as a respiratory stimulant and acts by increasing the sensitivity of peripheral chemoreceptors to hypoxia. The compound is a salt formed from almitrine, a pyridine derivative, and two mesylate groups, which contribute to its solubility and stability in aqueous solutions. Almitrine bismesylate is typically administered in a pharmaceutical formulation, and its efficacy is attributed to its ability to improve ventilation and oxygen uptake. The compound is characterized by its relatively low toxicity profile when used as directed, although potential side effects may include gastrointestinal disturbances and neurological effects. Its pharmacokinetics involve absorption, distribution, metabolism, and excretion processes that are essential for its therapeutic action. Overall, almitrine bismesylate represents a significant advancement in the management of hypoxemia in patients with compromised respiratory function.

Formula: C₂₆H₂₉F₂N₇·2CH₄O₃S

InChI: InChI=1S/C26H29F2N7.CH4O3S/c1-3-13-29-24-31-25(30-14-4-2)33-26(32-24)35-17-15-34(16-18-35)23(19-5-9-21(27)10-6-19)20-7-11-22(28)12-8-20;1-5(2,3)4/h3-12,23H,1-2,13-18H2,(H2,29,30,31,32,33);1H3,(H,2,3,4)

InChI key: InChIKey=QLOOZWWKRKLKMX-UHFFFAOYSA-N

SMILES: C(N1CCN(CC1)C=2N=C(NCC=C)N=C(NCC=C)N2)(C3=CC=C(F)C=C3)C4=CC=C(F)C=C4.S(C)(=O)(=O)O

Synonyms:

• 1,3,5-Triazine-2,4-diamine, 6-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]-N,N′-di-2-propenyl-, dimethanesulfonate
• 1,3,5-Triazine-2,4-diamine, 6-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]-N²,N⁴-di-2-propen-1-yl-, methanesulfonate (1:2)
• 1,3,5-triazine-2,4-diamine, 6-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]-N~2~,N~4~-di-2-propen-1-yl-, methanesulfonate (1:1)
• 1-(4,6-Bis(allylamino)-2-s-triazinyl)-4-(4,4′-difluorobenzhydryl)piperazine bis(methane sulfonate)
• 1-(4,6-Diallylamino-2-triazinyl)-4-(di-p-fluorobenzhydryl)piperazine bis(methanesulfonate)
• 1-[4,6-Bis(allylamino)-s-triazin-2-yl]-4-(di-p-fluorobenzhydryl)piperazine bis(methanesulfonate)
• 6-{4-[bis(4-fluorophenyl)methyl]piperazin-1-yl}-N,N'-di(prop-2-en-1-yl)-1,3,5-triazine-2,4-diamine methanesulfonate (1:1)
• 6-{4-[bis(4-fluorophenyl)methyl]piperazin-1-yl}-N,N'-diprop-2-en-1-yl-1,3,5-triazine-2,4-diamine dimethanesulfonate
• Almitrine Dimesylate
• Almitrine bismesylate
• Almitrine bismethanesulfonate
• Almitrine dimethanesulfonate
• Almitrine mesylate
• Vectarion
• s-Triazine, 2,4-bis(allylamino)-6-[4-[bis(p-fluorophenyl)methyl]-1-piperazinyl]-, dimethanesulfonate

6-{4-[bis(4-fluorophenyl)methyl]piperazin-1-yl}-2-N,4-N-bis(prop-2-en-1-yl)-1,3,5-triazine-2,4-diamine; bis(methanesulfonic acid)

CAS: 29608-49-9

Formula: C₂₈H₃₇F₂N₇O₆S₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 669.7635

Ref: IN-DA00I5H1

Almitrine mesylate

CAS: 29608-49-9

Almitrine mesylate

Purity: ≥98%

Molecular weight: 669.76g/mol

Ref: 54-BUP11770

Almitrine mesylate

CAS: 29608-49-9

Almitrine mesylate targets Ca2+-dependent K+ channels in rat cells, used for chronic lung hypoxemia.

Formula: C₂₈H₃₇F₂N₇O₆S₂

Purity: 99.96%

Color and Shape: Coa

Molecular weight: 669.76

Ref: TM-T6978

Almitrine Bismesylate

Controlled Product

CAS: 29608-49-9

Applications Almitrine Bismesylate is used in the synthetic preparation of triazine derivatives as potent modulators of multidrug resistance.
References Dhainaut, A.; et al.: J. Med. Chem, 34, 2481 (1992)

Formula: C₂₈H₃₇F₂N₇O₆S₂

Color and Shape: Neat

Molecular weight: 669.76

Ref: TR-A575153

Almitrine dimesilate

CAS: 29608-49-9

Almitrine dimesilate is a bismesylate that has been approved for the treatment of primary pulmonary hypertension and chronic obstructive pulmonary disease. It is also used to treat autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis. Almitrine dimesilate binds to the respiratory tract mucous membranes and inhibits the release of histamine or leukotrienes by blocking histamine receptors. This drug also blocks almitrine-sensitive K+ channels in heart muscle cells, which results in decreased heart rate and lower blood pressure. Almitrine dimesilate has been shown to have anti-inflammatory effects and may be useful in treating infections caused by bacteria sensitive to this drug.

Formula: C₂₆H₂₉F₂N₇•(CH₄O₃S)₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 669.76 g/mol

Ref: 3D-EBA60849