CAS 2967475-56-3
:O-desmethyl Brinzolamide (hydrochloride)
Description:
O-desmethyl Brinzolamide (hydrochloride) is a chemical compound that serves as a carbonic anhydrase inhibitor, primarily used in the treatment of elevated intraocular pressure in conditions such as glaucoma. It is a derivative of Brinzolamide, which is known for its efficacy in reducing aqueous humor production in the eye. The compound is characterized by its ability to selectively inhibit the enzyme carbonic anhydrase II, leading to decreased bicarbonate production and subsequently lowering intraocular pressure. O-desmethyl Brinzolamide is typically presented as a hydrochloride salt, enhancing its solubility and stability in aqueous solutions. The compound is generally white to off-white in appearance and is soluble in water and organic solvents. Its pharmacological profile includes a favorable safety and tolerability profile, making it a valuable option in ocular therapeutics. As with many pharmaceuticals, its use may be accompanied by potential side effects, which should be monitored during treatment.
Formula:C11H19N3O5S3·ClH
Synonyms:- O-desmethyl Brinzolamide (hydrochloride)
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O-Desmethyl Brinzolamide hydrochloride
CAS:<p>O-Desmethyl Brinzolamide hydrochloride (compound 6a), a potent metabolite derived from Brinzolamide, serves as a carbonic anhydrase (CA) inhibitor. It exhibits a dissociation constant (Kd) of 0.136 nM for CA II and an inhibitory concentration (IC50) of 165 nM for CA IV [1].</p>Formula:C11H20ClN3O5S3Color and Shape:SolidMolecular weight:405.94
