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CAS 29702-43-0

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2-Fluoro-2-deoxy-D-glucose

Description:
2-Fluoro-2-deoxy-D-glucose (FDG) is a synthetic analog of glucose, where the hydroxyl group at the second carbon is replaced by a fluorine atom. This modification imparts unique properties that make FDG particularly valuable in medical imaging, especially in positron emission tomography (PET) scans. The presence of the fluorine atom allows for the radiolabeling of the molecule, enabling visualization of metabolic processes in vivo. FDG is a white to off-white crystalline powder that is soluble in water, and it is typically administered in a sterile form for diagnostic purposes. Biochemically, FDG is taken up by cells in a manner similar to glucose, but it is not metabolized further due to the absence of a hydroxyl group, leading to its accumulation in tissues with high glucose metabolism, such as tumors. This characteristic makes FDG a crucial tool in oncology for detecting and monitoring cancer. Additionally, it has applications in research related to glucose metabolism and various metabolic disorders.
Formula:C6H11FO5
InChI:InChI=1S/C6H11FO5/c7-3(1-8)5(11)6(12)4(10)2-9/h1,3-6,9-12H,2H2/t3-,4+,5+,6+/m0/s1
InChI key:InChIKey=AOYNUTHNTBLRMT-SLPGGIOYSA-N
SMILES:[C@H]([C@@H]([C@@H](CO)O)O)([C@H](C=O)F)O
Synonyms:
  • 2-Deoxy-2-Fluorohexopyranose
  • 2-Deoxy-2-fluoro-<span class="text-smallcaps">D</span>-glucopyranose
  • 2-Deoxy-2-fluoro-<span class="text-smallcaps">D</span>-glucose
  • 2-Deoxy-2-fluoro-D-glucose
  • 2-Deoxy-2-fluoroglucose
  • 2-Deoxy-fluoro-glucose
  • 2-Fluoro-2-deoxy-<span class="text-smallcaps">D</span>-glucose
  • 2-Fluorodeoxyglucose
  • 2-fluoro-2-deoxy-D-glucose
  • 2-fluoro-2-deoxy-D-glucose, mixture of anomers
  • See more synonyms
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