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CAS 2976498-55-0

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  • PDEδ/NAMPT IN-1
    Targetmol
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    PDEδ/NAMPT IN-1

    CAS:
    <p>PDEδ/NAMPT IN-1 (Compound 17d) is a dual inhibitor targeting phosphodiesterase 6 (PDE6) with a dissociation constant (KD) of 0.410 nM and nicotinamide phosphoribosyltransferase (NAMPT) with an inhibitory concentration (IC50) of 2.21 nM. It disrupts KRAS-related signaling by inhibiting NAMPT's role in the synthesis of nicotinamide adenine dinucleotide (NAD+), consequently inducing apoptosis in pancreatic cancer cells with KRAS mutations. This compound holds potential for research in KRAS-mutant pancreatic cancer.</p>
    Formula:C26H30N4O4S
    Color and Shape:Solid
    Molecular weight:494.61

    Ref: TM-T207578