CAS 298-81-7

8-Methoxypsoralen

Description:

8-Methoxypsoralen, also known as 8-MOP, is a naturally occurring compound belonging to the class of furanocoumarins. It is primarily derived from the seeds of the plant Psoralea corylifolia. This substance is characterized by its ability to absorb ultraviolet (UV) light, which makes it useful in photochemotherapy, particularly for treating skin conditions such as psoriasis and vitiligo. 8-Methoxypsoralen acts as a photosensitizer, enhancing the effects of UVA radiation on affected skin. Chemically, it features a methoxy group (-OCH3) at the 8-position of the psoralen structure, contributing to its biological activity. The compound is typically a white to off-white crystalline solid and is soluble in organic solvents like ethanol and dimethyl sulfoxide, but has limited solubility in water. Due to its photosensitizing properties, caution is advised when handling 8-Methoxypsoralen, as it can increase the risk of skin reactions upon exposure to sunlight. Additionally, it has been studied for its potential effects on DNA and cellular processes, highlighting its significance in both therapeutic and research contexts.

Formula: C₁₂H₈O₄

InChI: InChI=1/C12H8O4/c1-14-12-10-8(4-5-15-10)6-7-2-3-9(13)16-11(7)12/h2-6H,1H3

InChI key: InChIKey=QXKHYNVANLEOEG-UHFFFAOYSA-N

SMILES: O(C)C=1C2=C(C=C3C1OC=C3)C=CC(=O)O2

Synonyms:

• 5-Benzofuranacrylic acid, 6-hydroxy-7-methoxy-, δ-lactone
• 5-Demethoxyisoimpinellin
• 6-Hydroxy-7-Methoxy-5-Benzofuranacrylic Acid Delta-Lactone
• 6-Hydroxy-7-methoxy-5-benzofuranacrylic acid-γ-lactone
• 7-Furocoumarin
• 7H-Furo[3,2-g][1]benzopyran-7-one, 9-methoxy-
• 8-Methoxy
• 8-Methoxy-2',3',6,7-Furocoumarin
• 8-Methoxy-4',5':6,7-furocoumarin
• 8-Methoxy-6,7-furanocoumarin
• 8-Methoxy[furano-3',2':6,7-coumarin]
• 8-Methoxy[furano-3′,2′:6,7-coumarin]
• 8-Methoxyfuranocoumarin
• 8-Methoxypsoralen
• 8-Methoxypsoralene
• 8-Mop
• 8-Mp
• 9-Methoxy-7H-furo[3,2-g] [1]benzopyran-7-one
• 9-Methoxyfuro[3,2-G]Chromen-7-One
• 9-Methoxyfuro[3,2-G]Chromene-7-One
• 9-Methoxyfuro[3,2-g]chromen-7-on
• 9-Methoxypsoralen
• 9-Metoxifuro[3,2-G]Cromen-7-Ona
• 9-methoxy-7H-furo(3,2-g)benzopyran-7-one
• 9-methoxy-7H-furo[3,2-g]chromen-7-one
• Ammodin
• Ammoidin
• Deltapsoralen
• Geroxalen
• MOP
• Meladinin
• Meladinine
• Meladoxen
• Meloxine
• Methoxa-Dome
• Methoxalen
• Methoxsalene
• New-Meladinin
• Nsc 45923
• Oxsoralen
• Oxsoralen Lotion
• Oxsoralen Ultra
• Oxypsoralen
• Proralone-Mop
• Psoralen-Mop
• Psoralon-MOP
• Puvalen
• Puvamet
• Uvadex
• Vitpso
• Xanthotoxin
• Xanthotoxine
• Xanthoxin
• Zanthotoxin
• 2-g)(1)benzopyran-7-one,9-methoxy-7h-furo(
• 6-Hydroxy-7-methoxy-5-benzofuranacrylic acid gamma-lactone
• 6-hydroxy-7-methoxy-5-benzofuranacrylicacidelta-lactone
• AKOS 214-64
• 5-Benzofuranacrylic acid, 6-hydroxy-7-methoxy-, delta-lactone
• 6-hydroxy-7-methoxy-5-benzofuranacrylicaciddelta-lactone
• 5-Benzofuranacrylicacid,6-hydroxy-7-methoxy-,δ-lactone
• 2-g][1]benzopyran-7-one,9-methoxy-7h-furo[
• 9-METHOXYFURO[3,2-G][1]BENZOPYRAN-7-ONE
• METHOXSALEN

Xanthotoxin

CAS: 298-81-7

Formula: C₁₂H₈O₄

Purity: >98.0%(GC)

Color and Shape: White to Orange to Green powder to crystal

Molecular weight: 216.19

Ref: 3B-X0009

8-Methoxypsoralen, 98%

CAS: 298-81-7

8-Methoxypsoralen, is used in Photochemotherapy (methoxsalen with long wave ultraviolet radiation) is indicated for the repigmentation of idiopathic vitiligo. It is also used in Photopheresis (methoxsalen with long wave ultraviolet radiation of white blood cells) is indicated for use with the UVAR

Formula: C₁₂H₈O₄

Purity: 98%

Color and Shape: White to pale cream or pale yellow, Crystals or powder or crystalline powder

Molecular weight: 216.19

Ref: 02-A17108

Xanthotoxin

CAS: 298-81-7

Xanthotoxin analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.

Formula: C₁₂H₈O₄

Purity: (HPLC) ≥90%

Color and Shape: Powder

Molecular weight: 216.19

Ref: 11-0530

Methoxsalen

CAS: 298-81-7

Color and Shape: Neat

Ref: 61-FOR0555.00

Methoxsalen

CAS: 298-81-7

Aromatic lactones used as drugs

Formula: C₁₂H₈O₄

Color and Shape: Off-White Powder

Molecular weight: 216.04226

Ref: 45-1417001

9-methoxy-2H-furo[3,2-g]chromen-2-one

CAS: 298-81-7

Formula: C₁₂H₈O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 216.1895

Ref: IN-DA00I5IO

Methoxsalen

CAS: 298-81-7

Methoxsalen (NCI-C55903) is a Photoactivated Radical Generator and Psoralen. The mechanism of action of methoxsalen is as a Photoabsorption. The physiologic effect of methoxsalen is by means of Photosensitizing Activity.

Formula: C₁₂H₈O₄

Purity: 99.47% - 99.86%

Color and Shape: Silky Needles From Hot Water Or Benzene + Petroleum Ether Tingling Sensation (Ntp 1992)

Molecular weight: 216.19

Ref: TM-T1548

Methoxsalen

CAS: 298-81-7

Formula: C₁₂H₈O₄

Molecular weight: 216.20

Ref: 4Z-M-072

Methoxsalen

CAS: 298-81-7

Methoxsalen

Purity: ≥98%

Molecular weight: 216.19g/mol

Ref: 54-BUP14558

8-Methoxypsoralen

CAS: 298-81-7

8-Methoxypsoralen

Purity: 98%

Molecular weight: 216.19g/mol

Ref: 54-OR1012097

Xanthotoxin

CAS: 298-81-7

Formula: C₁₂H₈O₄

Purity: ≥ 98.0%

Color and Shape: White to yellow powder or crystals

Molecular weight: 216.20

Ref: 7W-GP5578

9-Methoxy-7H-furo[3,2-g]chromen-7-one

CAS: 298-81-7

Purity: 95.0%

Color and Shape: Solid, White to pale yellow

Molecular weight: 216.19200134277344

Ref: 10-F239129

Xanthotoxin

CAS: 298-81-7

Formula: C₁₂H₈O₄

Purity: 95%~99%

Molecular weight: 216.192

Ref: BP-BP0936

Methoxsalen

CAS: 298-81-7

Formula: C₁₂H₈O₄

Color and Shape: Neat

Molecular weight: 216.19

Ref: 04-C15058500

Methoxsalen

Controlled Product

CAS: 298-81-7

Formula: C₁₂H₈O₄

Color and Shape: Light Yellow Solid

Molecular weight: 216.19

Ref: 86-MM0555.00

Methoxsalen RS

CAS: 298-81-7

Color and Shape: White To Cream Solid

Ref: 2K-1166000021

Xanthotoxin

CAS: 298-81-7

Lactone

Formula: C₁₂H₈O₄

Purity: ≥ 95.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 216.19

Ref: 5G-89866

8-Methoxy Psoralen

Controlled Product

CAS: 298-81-7

Applications Naturally occurring analog of Psoralen (P839800). Use in treatment of psoriasis and mycosis fungoides.
References Loutfy, M.A., et al.: Anal. Profiles Drug Subs., 9, 427 (1980), Parrish, J.A., et al.: Int. J. Dermatol., 19, 379 (1980),

Formula: C₁₂H₈O₄

Color and Shape: Neat

Molecular weight: 216.19

Ref: TR-M260795

8-Methoxypsoralen

CAS: 298-81-7

8-Methoxypsoralen is a furocoumarin compound, which is derived from natural plant sources such as the seeds of the Ammi majus plant. Its primary mode of action involves intercalation into DNA strands and the formation of covalent bonds with pyrimidine bases upon exposure to ultraviolet A (UVA) light. This interaction results in the inhibition of DNA synthesis and cell proliferation.

Formula: C₁₂H₈O₄

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 216.19 g/mol

Ref: 3D-FM08242