CAS 298-81-7

8-Methoxypsoralen

Description:

8-Methoxypsoralen, also known as 8-MOP, is a naturally occurring compound belonging to the class of furanocoumarins. It is primarily derived from the seeds of the plant Psoralea corylifolia. This substance is characterized by its ability to absorb ultraviolet (UV) light, which makes it useful in photochemotherapy, particularly for treating skin conditions such as psoriasis and vitiligo. 8-Methoxypsoralen acts as a photosensitizer, enhancing the effects of UVA radiation on affected skin. Chemically, it features a methoxy group (-OCH3) at the 8-position of the psoralen structure, contributing to its biological activity. The compound is typically a white to off-white crystalline solid and is soluble in organic solvents like ethanol and dimethyl sulfoxide, but has limited solubility in water. Due to its photosensitizing properties, caution is advised when handling 8-Methoxypsoralen, as it can increase the risk of skin reactions upon exposure to sunlight. Additionally, it has been studied for its potential effects on DNA and cellular processes, highlighting its significance in both therapeutic and research contexts.

Formula: C₁₂H₈O₄

InChI: InChI=1/C12H8O4/c1-14-12-10-8(4-5-15-10)6-7-2-3-9(13)16-11(7)12/h2-6H,1H3

InChI key: InChIKey=QXKHYNVANLEOEG-UHFFFAOYSA-N

SMILES: O(C)C=1C2=C(C=C3C1OC=C3)C=CC(=O)O2

Synonyms:

• 5-Benzofuranacrylic acid, 6-hydroxy-7-methoxy-, δ-lactone
• 5-Demethoxyisoimpinellin
• 6-Hydroxy-7-Methoxy-5-Benzofuranacrylic Acid Delta-Lactone
• 6-Hydroxy-7-methoxy-5-benzofuranacrylic acid-γ-lactone
• 7-Furocoumarin
• 7H-Furo[3,2-g][1]benzopyran-7-one, 9-methoxy-
• 8-Methoxy
• 8-Methoxy-2',3',6,7-Furocoumarin
• 8-Methoxy-4',5':6,7-furocoumarin
• 8-Methoxy-6,7-furanocoumarin
• 8-Methoxy[furano-3',2':6,7-coumarin]
• 8-Methoxy[furano-3′,2′:6,7-coumarin]
• 8-Methoxyfuranocoumarin
• 8-Methoxypsoralen
• 8-Methoxypsoralene
• 8-Mop
• 8-Mp
• 9-Methoxy-7H-furo[3,2-g] [1]benzopyran-7-one
• 9-Methoxyfuro[3,2-G]Chromen-7-One
• 9-Methoxyfuro[3,2-G]Chromene-7-One
• 9-Methoxyfuro[3,2-g]chromen-7-on
• 9-Methoxypsoralen
• 9-Metoxifuro[3,2-G]Cromen-7-Ona
• 9-methoxy-7H-furo(3,2-g)benzopyran-7-one
• 9-methoxy-7H-furo[3,2-g]chromen-7-one
• Ammodin
• Ammoidin
• Deltapsoralen
• Geroxalen
• MOP
• Meladinin
• Meladinine
• Meladoxen
• Meloxine
• Methoxa-Dome
• Methoxalen
• Methoxsalene
• New-Meladinin
• Nsc 45923
• Oxsoralen
• Oxsoralen Lotion
• Oxsoralen Ultra
• Oxypsoralen
• Proralone-Mop
• Psoralen-Mop
• Psoralon-MOP
• Puvalen
• Puvamet
• Uvadex
• Vitpso
• Xanthotoxin
• Xanthotoxine
• Xanthoxin
• Zanthotoxin
• 2-g)(1)benzopyran-7-one,9-methoxy-7h-furo(
• 6-Hydroxy-7-methoxy-5-benzofuranacrylic acid gamma-lactone
• 6-hydroxy-7-methoxy-5-benzofuranacrylicacidelta-lactone
• AKOS 214-64
• 5-Benzofuranacrylic acid, 6-hydroxy-7-methoxy-, delta-lactone
• 6-hydroxy-7-methoxy-5-benzofuranacrylicaciddelta-lactone
• 5-Benzofuranacrylicacid,6-hydroxy-7-methoxy-,δ-lactone
• 2-g][1]benzopyran-7-one,9-methoxy-7h-furo[
• 9-METHOXYFURO[3,2-G][1]BENZOPYRAN-7-ONE
• METHOXSALEN

8-Methoxypsoralen

CAS: 298-81-7

8-Methoxypsoralen is a furocoumarin compound, which is derived from natural plant sources such as the seeds of the Ammi majus plant. Its primary mode of action involves intercalation into DNA strands and the formation of covalent bonds with pyrimidine bases upon exposure to ultraviolet A (UVA) light. This interaction results in the inhibition of DNA synthesis and cell proliferation.

Formula: C₁₂H₈O₄

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 216.19 g/mol

Ref: 3D-FM08242

Methoxsalen RS

CAS: 298-81-7

Color and Shape: White To Cream Solid

Ref: 2K-1166000021