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CAS 2982511-19-1

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  • DNMT1-IN-5
    Targetmol
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    DNMT1-IN-5

    CAS:
    <p>DNMT1-IN-5 (Compound 55) is an inhibitor of DNMT, specifically targeting DNMT1 and DNMT3A, with IC50 values of 2.42 μM and 14.4 μM, respectively. It demonstrates antiproliferative effects across various cancer cell lines (TMD-8, DOHH2, MOLM-13, THP-1, RPIM-8226, and HCT116) with IC50 values ranging from 0.19 to 2.37 μM. The compound induces G2/M phase cell cycle arrest and apoptosis in TMD-8 and DOHH2 cells. Additionally, DNMT1-IN-5 exhibits antitumor efficacy in a TMD-8 xenograft mouse model.</p>
    Formula:C24H32FN7
    Color and Shape:Solid
    Molecular weight:437.556

    Ref: TM-T205711