CAS 29826-16-2

Dihydronovobiocin

Description:

Dihydronovobiocin is a chemical compound that belongs to the class of antibiotics known as novobiocin derivatives. It is characterized by its structure, which includes a coumarin core, and is known for its antibacterial properties, particularly against certain Gram-positive bacteria. The compound exhibits a mechanism of action that involves the inhibition of bacterial DNA gyrase, an essential enzyme for DNA replication and transcription. Dihydronovobiocin is typically studied for its potential therapeutic applications and its role in understanding antibiotic resistance. Its solubility and stability can vary depending on the formulation and conditions, which are important factors in its biological activity and efficacy. As with many antibiotics, the development of resistance can limit its effectiveness, making ongoing research into its pharmacological properties and potential modifications crucial for enhancing its utility in clinical settings. Safety and toxicity profiles are also important considerations in the development and application of this compound.

Formula: C₃₁H₃₈N₂O₁₁

InChI: InChI=1S/C31H38N2O11/c1-14(2)7-8-16-13-17(9-11-19(16)34)27(37)33-21-22(35)18-10-12-20(15(3)24(18)42-28(21)38)41-29-23(36)25(43-30(32)39)26(40-6)31(4,5)44-29/h9-14,23,25-26,29,34-36H,7-8H2,1-6H3,(H2,32,39)(H,33,37)/t23-,25+,26-,29-/m1/s1

InChI key: InChIKey=JJYCENBZIMIWTM-KGSXXDOSSA-N

SMILES: CC1=C2C(C(O)=C(NC(=O)C3=CC(CCC(C)C)=C(O)C=C3)C(=O)O2)=CC=C1O[C@H]4[C@H](O)[C@H](OC(N)=O)[C@@H](OC)C(C)(C)O4

Synonyms:

• Novobiocin, dihydro-
• N-[7-[[3-O-(Aminocarbonyl)-6-deoxy-5-C-methyl-4-O-methyl-α-L-lyxo-hexopyranosyl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-4-hydroxy-3-(3-methylbutyl)benzamide
• Dihydronovobiocin
• Benzamide, N-[7-[[3-O-(aminocarbonyl)-6-deoxy-5-C-methyl-4-O-methyl-α-L-lyxo-hexopyranosyl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-4-hydroxy-3-(3-methylbutyl)-

Dihydronovobiocin

CAS: 29826-16-2

Dihydronovobiocin: a coumarin antibiotic; fights S. aureus, S. haemolyticus, and others; inhibits DNA gyrase B (IC50: 64.5 nM).

Formula: C₃₁H₃₈N₂O₁₁

Color and Shape: Solid

Molecular weight: 614.64

Ref: TM-T37721