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CAS 2986745-48-4

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  • Osunprotafib hydrochloride
    Targetmol
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    Osunprotafib hydrochloride

    CAS:
    Osunprotafib (ABBV-CLS-484) hydrochloride is an orally active, selective inhibitor targeting the active sites of PTPN1 (IC50: 2.5 nM) and PTPN2 (IC50: 1.8 nM). It shows 6-8 times weaker activity towards PTPN9 and no detectable activity against SHP-1 or SHP-2. This compound enhances the sensitivity of human cancer cell lines to IFNγ. By boosting JAK-STAT signaling and reducing T cell dysfunction, Osunprotafib hydrochloride exhibits potent antitumor immunity.
    Formula:C17H25ClFN3O4S
    Color and Shape:Solid
    Molecular weight:421.92

    Ref: TM-T211442