CAS 29868-97-1
:Pirenzepine hydrochloride
Description:
Pirenzepine hydrochloride is a synthetic compound primarily classified as an antimuscarinic agent, which means it selectively inhibits the action of acetylcholine at muscarinic receptors. This characteristic makes it useful in the treatment of various gastrointestinal disorders, particularly peptic ulcers, by reducing gastric acid secretion. The substance is typically presented as a white to off-white crystalline powder, which is soluble in water and exhibits a pH range that is generally neutral. Its chemical structure includes a pyridine ring, contributing to its pharmacological properties. Pirenzepine hydrochloride is known for its relatively low side effect profile compared to other anticholinergic drugs, making it a preferred choice in certain therapeutic contexts. Additionally, it has been studied for potential applications beyond gastrointestinal issues, including its effects on the central nervous system. As with any medication, its use should be guided by a healthcare professional, considering potential interactions and contraindications.
Formula:C19H21N5O2·2ClH
InChI:InChI=1S/C19H21N5O2.2ClH/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24;;/h2-8H,9-13H2,1H3,(H,21,26);2*1H
InChI key:InChIKey=FFNMBRCFFADNAO-UHFFFAOYSA-N
SMILES:C(CN1CCN(C)CC1)(=O)N2C=3C(NC(=O)C=4C2=CC=CC4)=CC=CN3.Cl
Synonyms:- 11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one dihydrochloride
- 11-[2-(4-methylpiperazin-1-yl)acetyl]-5H-pyrido[2,3-b][1,4]benzodiazepin-6-one hydrate hydrochloride
- 5,11-Dihydro-11-((4-methylpiperazin-1-yl)acetyl)-6H-pyrido(2,3-b)-(1,4)benzodiazepin-6-one dihydrochloride
- 5,11-Dihydro-11-[(4-methyl-1-piperazinyl)acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one dihydrochloride
- 6H-Pyrido[2,3-b][1,4]benzodiazepin-6-one, 5,11-dihydro-11-[(4-methyl-1-piperazinyl)acetyl]-, dihydrochloride
- 6H-Pyrido[2,3-b][1,4]benzodiazepin-6-one, 5,11-dihydro-11-[2-(4-methyl-1-piperazinyl)acetyl]-, hydrochloride (1:2)
- Duogastral
- Durapirenz
- Gasteril
- Gastricur
- Gastrozepin
- L-S 519
- LS 519Cl<sub>2</sub>
- LS 59Cl2
- Leblon
- Maghen
- Pirenzepine HCL
- Pirenzepine Hcl Hydrate
- Pirenzepine Hydrochloride
- Renzepin
- Ulcosan
- Ulcuforton
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Found 13 products.
Pirenzepine Dihydrochloride
CAS:Formula:C19H21N5O2·2HClPurity:>98.0%(T)(HPLC)Color and Shape:White to Yellow to Orange powder to crystalMolecular weight:424.33Pirenzepine dihydrochloride, 99%
CAS:A M1 muscarinic receptor antagonist
Formula:C19H23Cl2N5O2Purity:99%Color and Shape:Crystals or powder or crystalline powder, White to pale yellowMolecular weight:424.33PIRENZEPINE DIHYDROCHLORIDE MONOHYDRATE CRS
CAS:PIRENZEPINE DIHYDROCHLORIDE MONOHYDRATE CRSFormula:C19H23Cl2N5O2Color and Shape:Crystalline Powder. White. Light Yellow. Powder., Crystalline Powder. White. Light Yellow. Powder.Molecular weight:424.3242Pirenzepine dihydrochloride
CAS:Pirenzepine dihydrochloride (LS519) is a selective M1 muscarinic receptor antagonist, inhibiting gastric secretion.Formula:C19H21N5O2·2HClPurity:99.48% - 99.62%Color and Shape:White PowderMolecular weight:424.32Pirenzepine dihydrochloride
CAS:Formula:C19H21N5O2·2HClPurity:98.0 - 102.0 % (dried basis)Color and Shape:White to off-white or pale yellow powderMolecular weight:424.32Pirenzepine, Dihydrochloride
CAS:Controlled ProductApplications An antiulcerative. Tricyclic gastric-acid inhibitor.
References Eberlein, W., et al.: Arzneimittel-Forsch., 27, 356 (1977), Hellerr, G., et al.: Verh. Deut. Ges. Inn. Med., 84, 991 (1978), Carmine, A.A., et al.: Drugs, 30,85 (1985), El-Obeid, H.A., et al.: Anal. Profiles Drug Subs., 16, 445 (1987), Homon, C.A., et al.: Ther. Drug Monit., 9, 236 (1987),Formula:C19H21N5O2·2ClHColor and Shape:NeatMolecular weight:424.32Pirenzepine-d8 Dihydrochloride
CAS:Controlled ProductFormula:C19H15D8Cl2N5O2Color and Shape:NeatMolecular weight:432.37Pirenzepine dihydrochloride
CAS:Pirenzepine is a nonsteroidal anti-inflammatory drug and prokinetic agent used to treat bowel disease. It is also used to treat pancreatic enzyme deficiency, which can result in chronic diarrhea. Pirenzepine has been shown to inhibit protease activity in mouse serum, and it has been reported that this inhibition may be due to its ability to bind with amyloid protein and prevent amyloid aggregation. Pirenzepine also suppresses inflammatory responses by inhibiting the production of inflammatory mediators such as leukotrienes, prostaglandins, and cytokines, thereby providing therapeutic benefits for treating chronic bronchitis and other inflammatory diseases. Pirenzepine is metabolized in the liver by the cytochrome P450 enzyme system into an active form called pirenzepine N-oxide. This active form is then metabolized by hydrolysis or glucuronidation before excretion from the body. The most common sideFormula:C19H23Cl2N5O2Purity:Min. 95%Color and Shape:White PowderMolecular weight:424.32 g/molPirenzepine-d10 Dihydrochloride
CAS:Controlled ProductApplications Pirenzepine-d10 Dihydrochloride is an analogue of Pirenzepine (P508500), an antiucerative agent that works by inhibiting tricyclic gastric-acid secretion.
References Fliri, A . F., et al.: J. Med. Chem., 52, 8038 (2009); Eberlein, W., et al.: Arzneimittel-Forsch., 27, 356 (1977), Hellerr, G., et al.: Verh. Deut. Ges. Inn. Med., 84, 991 (1978), Carmine, A.A., et al.: Drugs, 30,85 (1985), El-Obeid, H.A., et al.: Anal. Profiles Drug Subs., 16, 445 (1987), Homon, C.A., et al.: Ther. Drug Monit., 9, 236 (1987),Formula:C19H12D11Cl2N5O2Color and Shape:BrownMolecular weight:435.39
