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CAS 2987886-49-5

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  • cGAS-IN-4
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    cGAS-IN-4

    CAS:
    <p>cGAS-IN-4 (Compound 36) is an orally active inhibitor of cyclic GMP-AMP synthase (cGAS) with IC50 values of 32 nM for human cGAS (h-cGAS) and 5.8 nM for mouse cGAS (m-cGAS). In THP-1 cells, cGAS-IN-4 inhibits cGAMP with an IC50 of 60 nM, enhancing cellular potency. Additionally, cGAS-IN-4 exhibits anti-inflammatory effects in a mouse model of Concanavalin A-induced acute liver injury.</p>
    Formula:C19H18Cl2N4O3
    Color and Shape:Solid
    Molecular weight:421.277

    Ref: TM-T204612