CAS 29908-03-0

S-Adenosyl-L-methionine

Description:

S-Adenosyl-L-methionine (often abbreviated as SAM or SAMe) is a naturally occurring compound that plays a crucial role in various biological processes, particularly in methylation reactions. It is a sulfonium compound derived from the amino acid methionine and adenosine triphosphate (ATP). SAMe is characterized by its high reactivity due to the presence of a positively charged sulfur atom, which facilitates the transfer of methyl groups to various substrates, including DNA, proteins, and lipids. This methylation process is vital for gene expression regulation, neurotransmitter synthesis, and the maintenance of cellular function. SAMe is also involved in the synthesis of important biomolecules, such as phosphatidylcholine and creatine. In addition to its biological significance, SAMe has been studied for its potential therapeutic effects, particularly in mood disorders and liver health. It is generally considered safe for use as a dietary supplement, although individuals should consult healthcare professionals before starting any new treatment regimen.

Formula: C₁₅H₂₂N₆O₅S

InChI: InChI=1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/t7-,8+,10+,11+,14+,27?/m0/s1

InChI key: InChIKey=MEFKEPWMEQBLKI-AIRLBKTGSA-N

SMILES: O[C@H]1[C@H](N2C=3C(N=C2)=C(N)N=CN3)O[C@H](C[S+](CC[C@@H](C([O-])=O)N)C)[C@H]1O

Synonyms:

• (2S)-2-amino-4-[{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}(methyl)sulfonio]butanoate (non-preferred name)
• (3-amino-3-carboxypropyl){[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}methylsulfonium (non-preferred name)
• (3-amino-3-carboxypropyl){[5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}methylsulfonium (non-preferred name)
• (3S)-5'-[(3-Amino-3-carboxylatopropyl)methylsulfonio]-5'-desoxyadenosin
• (3S)-5'-[(3-amino-3-carboxilatopropil)metilsulfonio]-5'-desoxiadenosina
• (3S)-5'-[(3-amino-3-carboxylatopropyl)methylsulfonio]-5'-desoxyadenosine
• (3S)-5'-[(3-amino-3-carboxylatopropyl)methylsulphonio]-5'-deoxyadenosine
• 2-amino-4-[{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}(methyl)sulfonio]butanoate (non-preferred name)
• 5-Deoxyadenosine-5-L-methionine disulfate ditosylate
• <span class="text-smallcaps">L</span>-Methionine, S-adenosyl-
• <span class="text-smallcaps">L</span>-S-Adenosylmethionine
• Active methionine
• Ademetionine
• Adenosine, 5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxy-, hydroxide, inner salt, (3S)-
• Adenosine, 5'-[(L-3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxy-, hydroxide, inner salt
• Adenosine, 5'-[[(3S)-3-amino-3-carboxypropyl]methylsulfonio]-5'-deoxy-, inner salt
• Adenosine, 5′-[(<span class="text-smallcaps">L</span>-3-amino-3-carboxypropyl)methylsulfonio]-5′-deoxy-, hydroxide, inner salt
• Adenosyl-<span class="text-smallcaps">L</span>-methionine
• AdoMet
• Donamet
• L-Methionine, S-adenosyl-
• L-S-Adenosylmethionine
• Methionine, S-adenosyl-
• S Amet
• S-(5-Adenosyl)-L-methionine
• S-Adenosyl methionine
• S-Adenosyl-<span class="text-smallcaps">L</span>-methionine
• S-Adenosyl-L-methionine
• S-Adenosylmethionine
• SAH (S-Adenosylmethionine)
• SAMe
• Transmetil

S-Adenosyl-L-methionine

CAS: 29908-03-0

Formula: C₁₅H₂₂N₆O₅S

Purity: 98%

Color and Shape: Solid

Molecular weight: 398.4374

Ref: IN-DA0035KP

S-Adenosyl-L-methionine

CAS: 29908-03-0

S-Adenosyl-L-methionine (Ademetionine) is an intermediate metabolite of methionine,for treatment of primary biliary cirrhosis and major depressive disorder.

Formula: C₁₅H₂₂N₆O₅S

Purity: 99.08%

Color and Shape: Solid

Molecular weight: 398.44

Ref: TM-T7475

S-Adenosyl-L-methionine

CAS: 29908-03-0

S-Adenosyl-L-methionine

Molecular weight: 398.44g/mol

Ref: 54-BUP21423

S-Adenosyl-L-methionine p-toluenesulfonate

CAS: 29908-03-0

Formula: C₁₅H₂₃N₆O₅S·C₇H₇O₃S

Purity: ≥ 95.0% (HPLC, dry basis)

Color and Shape: White crystalline powder, hygroscopic

Molecular weight: 570.64

Ref: 7W-GN3274

S-Adenosyl-L-Methionine

CAS: 29908-03-0

Formula: C₁₅H₂₂N₆O₅S

Molecular weight: 398.44

Ref: 4Z-A-106001

S-(5'-Adenosyl)-L-methionine-d3 Disulfate Salt (Synthetic)(Mixture of Diastereomers)

Controlled Product

CAS: 29908-03-0, 68684-40-2

Formula: C₁₅DH₃H₂₀N₆O₅S·HSO₄·H₂SO₄

Purity: >85%

Color and Shape: White To Yellow

Molecular weight: 597.612

Ref: TR-A291532

S-Adenosyl-L-methionine

CAS: 29908-03-0

S-Adenosyl-L-methionine (SAM-e) is a co-substrate involved in methyl group transfer to nucleic acids, proteins and lipids. SAM-e is produced in the liver from adenosine triphosphate (ATP) and methionine by action of the enzyme methionine adenosyltransferase. Therapeutic use of S-adenosyl-L-methionine includes osteoarthritis, liver disease and major depressive disorder. S-Adenosyl-L-methionine is available as a dietary supplement.

Formula: C₁₅H₂₂N₆O₅S

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 398.44 g/mol

Ref: 3D-NA16291