As of my last update in October 2023, TRK-IN-28, with the CAS number 2991504-43-7, is a chemical compound that has garnered attention in the field of medicinal chemistry, particularly for its potential therapeutic applications. While specific characteristics such as its molecular structure, physical properties, and biological activity may not be widely documented in public databases, compounds like TRK-IN-28 are typically evaluated for their efficacy as inhibitors or modulators of specific biological targets, often in the context of cancer or other diseases. The compound may exhibit properties such as solubility in various solvents, stability under certain conditions, and specific interactions with biological macromolecules. Researchers often conduct studies to determine its pharmacokinetics, toxicity, and mechanism of action. For detailed and specific information, including experimental data and safety profiles, consulting scientific literature or proprietary databases would be necessary, as these details can evolve with ongoing research.

TRK-IN-28

2991504-43-7: As of my last update in October 2023, TRK-IN-28, with the CAS number 2991504-43-7, is a chemical compound that has garnered attention in the field of medicinal chemistry, particularly for its potential therapeutic applications. While specific characteristics such as its molecular structure, physical properties, and biological activity may not be widely documented in public databases, compounds like TRK-IN-28 are typically evaluated for their efficacy as inhibitors or modulators of specific biological targets, often in the context of cancer or other diseases. The compound may exhibit properties such as solubility in various solvents, stability under certain conditions, and specific interactions with biological macromolecules. Researchers often conduct studies to determine its pharmacokinetics, toxicity, and mechanism of action. For detailed and specific information, including experimental data and safety profiles, consulting scientific literature or proprietary databases would be necessary, as these details can evolve with ongoing research.

TRK-IN-28 (compound 30f) functions as a TRK inhibitor, displaying potencies with IC 50 values of 0.55 nM for TRK WT, 25.1 nM for TRK G595R, and 5.4 nM for TRK G667C. Another TRK inhibitor, TRK-IN-2, exhibits antiproliferative effects with IC 50 values against multiple cell lines: 9.5 nM for Ba/F3-ETV6-TRKA WT, 3.7 nM for Ba/F3-ETV6-TRKB WT, 205.0 nM for Ba/F3-LMNA-TRK G595R, and 48.3 nM for Ba/F3-LMNA-TRKA G667C [1].

CAS 2991504-43-7

TRK-IN-28

TRK-IN-28

Ref: TM-T87570