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CAS 2994635-04-8

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  • BRD4 Inhibitor-40
    Targetmol
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    BRD4 Inhibitor-40

    CAS:
    <p>BRD4 Inhibitor-40 (Compound 23) functions as an inhibitor of BRD, effectively targeting BRD4-BD1, BRD4-BD2, BRD2-BD1, and BRD2-BD2, with IC50 values of 16.1, 142.18, 29.35, and 302.35 nM, respectively. It modulates the expression of c-Myc and p21, induces cell cycle arrest in the G1 phase, and inhibits Pkd1-deficient (PN) renal cystic epithelial cells. Additionally, it prevents renal cyst formation in both Madin-Darby canine kidney and embryonic kidney cyst models, and demonstrates renal cyst inhibition activity in mouse models.</p>
    Formula:C27H32N8O
    Color and Shape:Solid
    Molecular weight:484.596

    Ref: TM-T205510