CAS 2998-57-4

Estramustine

Description:

Estramustine is a synthetic compound that combines the properties of an estrogen and a nitrogen mustard, primarily used in the treatment of prostate cancer. It is classified as an antineoplastic agent, functioning by interfering with the growth and proliferation of cancer cells. The chemical structure of estramustine features a steroid nucleus, which is modified to enhance its therapeutic effects. It is typically administered orally and is known for its ability to bind to estrogen receptors, which may contribute to its anticancer activity. Estramustine is also characterized by its relatively low solubility in water, which can affect its bioavailability. Common side effects associated with its use include gastrointestinal disturbances, fatigue, and potential hormonal changes due to its estrogenic activity. As with many chemotherapeutic agents, careful monitoring is essential to manage adverse effects and assess treatment efficacy. Overall, estramustine represents a unique approach in cancer therapy, leveraging both hormonal and cytotoxic mechanisms to combat malignancies.

Formula: C₂₃H₃₁Cl₂NO₃

InChI: InChI=1/C23H31Cl2NO3/c1-23-9-8-18-17-5-3-16(29-22(28)26(12-10-24)13-11-25)14-15(17)2-4-19(18)20(23)6-7-21(23)27/h3,5,14,18-21,27H,2,4,6-13H2,1H3/t18-,19-,20+,21+,23+/m1/s1

InChI key: InChIKey=FRPJXPJMRWBBIH-RBRWEJTLSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@](C=4C(CC3)=CC(OC(N(CCCl)CCCl)=O)=CC4)(CC1)[H])[H])(CC[C@@H]2O)[H]

Synonyms:

• (17Beta)-17-Hydroxyestra-1,3,5(10)-Trien-3-Yl Bis(2-Chloroethyl)Carbamate
• 17-Hydroxyestra-1,3,5(10)-Trien-3-Yl Bis(2-Chloroethyl)Carbamate
• 17β-Estradiol 3-[bis(2-chloroethyl)carbamate]
• 2998-57-4
• Carbamic acid, bis(2-chloroethyl)-, 17β-hydroxyestra-1,3,5(10)-trien-3-yl ester
• Estra-1,3,5(10)-triene-3,17-diol (17β)-, 3-[bis(2-chloroethyl)carbamate]
• Estracty
• Estradiol 3-[N,N-bis(2-chloroethyl)carbamate]
• Estradiol, 3-[bis(2-chloroethyl)carbamate]
• Estramustin
• Estramustina
• Leo 275
• Nsc 89201
• Ro 22-2296/000
• β-Estradiol 3-[N,N-bis(2-chloroethyl)carbamate]
• Estramustine
• Estra-1,3,5(10)-triene-3,17-diol (17beta)-, 3-(bis(2-chloroethyl)carbamate)
• Estra-1,3,5(10)-triene-3,17-diol, 3-(bis(2-chloroethyl)carbamate), (17 beta)-
• 3,5(10)-triene-3,17-diol(17beta)-estra-3-(bis(2-chloroethyl)carbamate)
• 1,3,5(10)-Estratriene-3,17β-diol 3-[N,N-bis(2-chloroethyl)carbamate]
• ESTRAMUSTINE SODIUM PHOSPHATE
• 1,3,5(10)-Estratriene-3,17β-diol 3-[bis(2-chloroethyl)carbamate]
• Alestramustine
• Estamustine

disodium (1S,10R,11S,14S,15S)-5-{[bis(2-chloroethyl)carbamoyl]oxy}-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2(7),3,5-trien-14-yl phosphate

CAS: 2998-57-4

Formula: C₂₃H₃₁Cl₂NO₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 440.4031

Ref: IN-DA00BBV3

Estramustine

CAS: 2998-57-4

Estramustine

Purity: ≥98%

Molecular weight: 440.4g/mol

Ref: 54-BUP10803

Estramustine

Controlled Product

CAS: 2998-57-4

Formula: C₂₃H₃₁Cl₂NO₃

Color and Shape: Neat

Molecular weight: 440.40

Ref: 86-MM0100.01

Estramustine

CAS: 2998-57-4

Estramustine (LEO-275), a nitrogen mustard-estradiol compound, treats prostate cancer and protects against radiation.

Formula: C₂₃H₃₁Cl₂NO₃

Purity: 98.09%

Color and Shape: Solid

Molecular weight: 440.4

Ref: TM-T20681

Estramustine

CAS: 2998-57-4

Purity: 98%

Molecular weight: 440.4100036621094

Ref: 10-F601661

Estramustine

Controlled Product

CAS: 2998-57-4

Applications Estradiol 3-[N,N-Bis(2-chloroethyl)carbamate] is used treatment of breast cancer. Also used in the treatment of prostate cancer.
References Hilavac, V. et al.: Pharmacogenom., 14, 515 (2013);

Formula: C₂₃H₃₁Cl₂NO₃

Color and Shape: White

Molecular weight: 440.40

Ref: TR-E888075

Estramustine

CAS: 2998-57-4

DNA-alkylating agent; anti-cancer agent; estradiol derivative

Formula: C₂₃H₃₁Cl₂NO₃

Purity: Min. 99 Area-%

Molecular weight: 440.4 g/mol

Ref: 3D-FE37343

Estramustine

CAS: 2998-57-4

Estramustine

Color and Shape: White

Ref: 47-142