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CAS 2999646-19-2

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  • NDI-Lyso
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    NDI-Lyso

    CAS:
    <p>NDI-Lyso is an anticancer agent targeting lysosomes, functioning through an enzyme-induced self-assembly (EISA) mechanism catalyzed by Cathepsin B. In cancer cell lysosomes, it forms rigid long fibers, promoting lysosomal swelling, lysosomal membrane permeabilization (LMP), and membrane disruption. This leads to non-classical caspase-independent apoptosis (Apoptosis). NDI-Lyso demonstrates significant selective anticancer activity across various cancer cell lines and drug-resistant cancer cells (IC50 approximately 10 μM), while exhibiting low toxicity to normal cells (IC50 &gt; 60 μM).</p>
    Formula:C71H100N22O13
    Color and Shape:Solid
    Molecular weight:1469.69

    Ref: TM-TP2920