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CAS 3002409-47-1

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  • PRMT5-IN-50
    Targetmol
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    PRMT5-IN-50

    CAS:
    <p>PRMT5-IN-50 is an orally active selective inhibitor of PRMT5, demonstrating good metabolic stability and low clearance in human liver microsomes. It inhibits SDMA/HCT116-MTAPdel and SDMA/HCT116-MTAPwt with IC50 values for symmetric arginine methylation inhibition at 1.0 and 536 nM, respectively, and antiproliferative IC50 values at 19 and 1620 nM, respectively. Additionally, PRMT5-IN-50 suppresses tumor growth in mice.</p>
    Formula:C26H23F3N6O
    Color and Shape:Solid
    Molecular weight:492.496

    Ref: TM-T206754