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CAS 3002417-64-0

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  • HEMTAC WEE1 degrader-1
    Targetmol
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    HEMTAC WEE1 degrader-1

    CAS:
    <p>HEMTACWEE1degrader-1 is a WEE1-targeting heterobifunctional chimeric degrader (HEMTAC) facilitated by HSP90, exhibiting an HSP90 enzyme inhibitory activity with an IC50 of 16.76 nM. It enhances the ubiquitination and subsequent degradation of WEE1, effectively blocking the G2/M cell cycle transition. This compound shows anticancer properties in patient-derived xenograft (PDX) models of acute myeloid leukemia (AML). HEMTACWEE1degrader-1 is utilized in AML research.</p>
    Formula:C57H71N15O6
    Color and Shape:Solid
    Molecular weight:1062.27

    Ref: TM-T207012