FXR/CES2 modulator 1, identified by the CAS number 3004676-87-0, is a chemical compound that functions as a modulator of the farnesoid X receptor (FXR) and carboxylesterase 2 (CES2). FXR is a nuclear receptor that plays a crucial role in bile acid metabolism, lipid homeostasis, and glucose metabolism, making it a target for therapeutic interventions in metabolic diseases. The modulation of CES2, an enzyme involved in the hydrolysis of ester and amide bonds, can influence drug metabolism and bioavailability. While specific physical and chemical properties such as solubility, melting point, and stability may vary, compounds in this category typically exhibit moderate to high potency in biological assays. The development of FXR/CES2 modulators is of significant interest in pharmacology, particularly for their potential applications in treating conditions like non-alcoholic fatty liver disease and dyslipidemia. As research progresses, understanding the precise mechanisms and effects of such modulators will be essential for their therapeutic application.

FXR/CES2 modulator 1

3004676-87-0: FXR/CES2 modulator 1, identified by the CAS number 3004676-87-0, is a chemical compound that functions as a modulator of the farnesoid X receptor (FXR) and carboxylesterase 2 (CES2). FXR is a nuclear receptor that plays a crucial role in bile acid metabolism, lipid homeostasis, and glucose metabolism, making it a target for therapeutic interventions in metabolic diseases. The modulation of CES2, an enzyme involved in the hydrolysis of ester and amide bonds, can influence drug metabolism and bioavailability. While specific physical and chemical properties such as solubility, melting point, and stability may vary, compounds in this category typically exhibit moderate to high potency in biological assays. The development of FXR/CES2 modulators is of significant interest in pharmacology, particularly for their potential applications in treating conditions like non-alcoholic fatty liver disease and dyslipidemia. As research progresses, understanding the precise mechanisms and effects of such modulators will be essential for their therapeutic application.

Compound LE-77, known as FXR/CES2 modulator 1, functions as a dual regulator that activates FXR and inhibits CES2. It effectively mitigates the intestinal toxicity of irinotecan.

CAS 3004676-87-0

FXR/CES2 modulator 1

FXR/CES2 modulator 1

Ref: TM-T200901