CAS 3007566-23-3

A2AR modulator-1

CAS: 3007566-23-3

A2AR modulator-1 (Compound 45) is a selective negative allosteric modulator of the adenosine A2a receptor (A2aR), with an IC50 value of 9 nM. It reduces the affinity of endogenous adenosine for the receptor and inhibits the activation of the cAMP signaling pathway. A2AR modulator-1 effectively restores pCREB phosphorylation in CD4+ T cells, reverses immunosuppression in the tumor microenvironment, and shows potential in inhibiting tumor growth and metastasis in a triple-negative breast cancer model.

Formula: C₂₃H₂₀N₆

Color and Shape: Solid

Molecular weight: 380.45

Ref: TM-T210624