CAS 3010273-12-5

PROTAC ATR degrader-2

Formula: C₄₀H₄₁N₉O₆

Synonyms:

• PROTAC ATR degrader-2

PROTAC ATR degrader-2

CAS: 3010273-12-5

PROTAC ATR degrader-2 (Compound 8i) serves as a PROTAC degrader targeting ATR, effectively degrading it in acute myeloid leukemia (AML) cell lines MV-4-11 and MOLM-13, with DC50 values of 22.9 and 34.5 nM, respectively. This compound induces apoptosis and inhibits the proliferation of AML cells. Additionally, PROTAC ATR degrader-2 demonstrates favorable pharmacokinetic properties and potent antitumor activity in a mouse model of AML.

Formula: C₄₀H₄₁N₉O₆

Color and Shape: Solid

Molecular weight: 743.81

Ref: TM-T87258