CAS 301544-78-5

Compstatin control peptide

Description:

Compstatin control peptide, with the CAS number 301544-78-5, is a synthetic peptide that serves as a potent inhibitor of the complement system, specifically targeting the complement component C3. This peptide is derived from a naturally occurring protein and is designed to modulate immune responses by preventing the activation of the complement pathway, which plays a crucial role in inflammation and immune defense. Compstatin is characterized by its ability to bind to C3, thereby inhibiting its cleavage and subsequent activation of downstream complement components. This property makes it a valuable tool in research related to autoimmune diseases, inflammatory conditions, and transplant rejection. The peptide is typically characterized by its stability, specificity, and efficacy in various biological assays. Additionally, it is often used in experimental settings to study the role of complement activation in disease processes and to explore potential therapeutic applications in complement-mediated disorders.

Formula: C₆₆H₁₀₁N₂₃O₁₇

Synonyms:

• (3S)-3-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-amino-3-methylpentanoyl]amino]propanoyl]amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-5-oxopentanoyl]amino]-4-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-4-oxobutanoic acid
• Compstatin control peptide
• L-Threoninamide, L-isoleucyl-L-alanyl-L-valyl-L-valyl-L-glutaminyl-L-α-aspartyl-L-tryptophylglycyl-L-histidyl-L-histidyl-L-arginyl-L-alanyl-

Compstatin control peptide acetate

CAS: 301544-78-5

Compstatin control peptide acetate is an inhibitor of complement protein C3 by binding and inhibiting the cleavage of complement C3.

Formula: C₆₆H₁₀₁N₂₃O₁₇

Purity: 99.02%

Color and Shape: Odour Solid

Molecular weight: 1488.65

Ref: TM-TP2180L

Compstatin control peptide

CAS: 301544-78-5

Compstatin is a peptide that is a potent inhibitor of potassium ion channels. Compstatin is an inhibitor of the voltage-gated potassium channel, Kv1.2, which plays a key role in the regulation of neuronal excitability. The Compstatin control peptide has been shown to inhibit the activity of Kv1.2 and other potassium channels such as Kv3.1, Kv3.4, and Kv7.2 at nanomolar concentrations in both native and recombinant systems with high affinity. This control peptide has also been shown to be capable of inhibiting ligand binding to receptors such as bradykinin B2 receptor and muscarinic M2 receptor with low micromolar concentrations with high potency

Formula: C₆₆H₁₀₁N₂₃O₁₇

Purity: Min. 95%

Molecular weight: 1,488.7 g/mol

Ref: 3D-BMA54478